4i4b: Difference between revisions
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== | ==HMG-CoA Reductase from Pseudomonas mevalonii complexed with NAD and intermediate hemiacetal form of HMG-CoA== | ||
[[http://www.uniprot.org/uniprot/MVAA_PSEMV MVAA_PSEMV | <StructureSection load='4i4b' size='340' side='right'caption='[[4i4b]], [[Resolution|resolution]] 1.70Å' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4i4b]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_mevalonii Pseudomonas mevalonii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I4B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4I4B FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1CO:(3S)-3-HYDROXY-3-METHYL-5-SULFANYLPENTANOIC+ACID'>1CO</scene>, <scene name='pdbligand=1CV:(3R,5R,9R,19R,21S)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9,21-tetrahydroxy-8,8,21-trimethyl-10,14-dioxo-19-sulfanyl-2,4,6-trioxa-18-thia-11,15-diaza-3,5-diphosphatricosan-23-oic+acid+3,5-dioxide'>1CV</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4i4b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i4b OCA], [https://pdbe.org/4i4b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4i4b RCSB], [https://www.ebi.ac.uk/pdbsum/4i4b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4i4b ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/MVAA_PSEMV MVAA_PSEMV] P.mevalonii can use mevalonate as sole carbon source. With this enzyme mevalonate is deacetylated to HMG-CoA. | |||
== | ==See Also== | ||
[[ | *[[HMG-CoA Reductase 3D structures|HMG-CoA Reductase 3D structures]] | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: | |||
[[Category: Pseudomonas mevalonii]] | [[Category: Pseudomonas mevalonii]] | ||
[[Category: Burgner | [[Category: Burgner JW]] | ||
[[Category: Critchelow | [[Category: Critchelow CJ]] | ||
[[Category: Min | [[Category: Min J]] | ||
[[Category: Rodwell | [[Category: Rodwell VW]] | ||
[[Category: Schmidt | [[Category: Schmidt T]] | ||
[[Category: Stauffacher | [[Category: Stauffacher CV]] | ||
[[Category: Steussy | [[Category: Steussy CN]] | ||
[[Category: Wrensford | [[Category: Wrensford LV]] | ||
Latest revision as of 11:49, 1 March 2024
HMG-CoA Reductase from Pseudomonas mevalonii complexed with NAD and intermediate hemiacetal form of HMG-CoA
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