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{{STRUCTURE_4g1p|  PDB=4g1p  |  SCENE=  }}
===Structural and Mechanistic Basis of Substrate Recognition by Novel Di-peptidase Dug1p From Saccharomyces cerevisiae===


==Function==
==Structural and Mechanistic Basis of Substrate Recognition by Novel Di-peptidase Dug1p From Saccharomyces cerevisiae==
[[http://www.uniprot.org/uniprot/DUG1_YEAST DUG1_YEAST]] Catalytic component of the GSH degradosomal complex involved in the degradation of glutathione (GSH) and other peptides containing a gamma-glu-X bond. Functions also in a DUG2-DUG3-independent manner as a dipeptidase with high specificity for Cys-Gly and no activity toward tri- or tetrapeptides.<ref>PMID:17179087</ref> <ref>PMID:19346245</ref>
<StructureSection load='4g1p' size='340' side='right'caption='[[4g1p]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[4g1p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G1P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G1P FirstGlance]. <br>
[[4g1p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G1P OCA].
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.547&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CYS:CYSTEINE'>CYS</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
==Reference==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g1p OCA], [https://pdbe.org/4g1p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g1p RCSB], [https://www.ebi.ac.uk/pdbsum/4g1p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g1p ProSAT]</span></td></tr>
<references group="xtra"/><references/>
</table>
[[Category: Saccharomyces cerevisiae s288c]]
== Function ==
[[Category: Kumaran, S.]]
[https://www.uniprot.org/uniprot/DUG1_YEAST DUG1_YEAST] Catalytic component of the GSH degradosomal complex involved in the degradation of glutathione (GSH) and other peptides containing a gamma-glu-X bond. Functions also in a DUG2-DUG3-independent manner as a dipeptidase with high specificity for Cys-Gly and no activity toward tri- or tetrapeptides.<ref>PMID:17179087</ref> <ref>PMID:19346245</ref>  
[[Category: Mittal, M.]]
== References ==
[[Category: Pandya, V K.]]
<references/>
[[Category: Singh, A K.]]
__TOC__
[[Category: Singh, M.]]
</StructureSection>
[[Category: Singh, V.]]
[[Category: Large Structures]]
[[Category: Alpha/beta scaffold]]
[[Category: Saccharomyces cerevisiae S288C]]
[[Category: Di-nuclear peptidase]]
[[Category: Kumaran S]]
[[Category: Hydrolase]]
[[Category: Mittal M]]
[[Category: M20 family metallo-peptidase]]
[[Category: Pandya VK]]
[[Category: N-terminal catalytic domain/c-terminal lid domain]]
[[Category: Singh AK]]
[[Category: Singh M]]
[[Category: Singh V]]
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