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{{STRUCTURE_4jrg|  PDB=4jrg  |  SCENE=  }}
===The 1.9A crystal structure of humanized Xenopus MDM2 with RO5313109 - a pyrrolidine MDM2 inhibitor===
{{ABSTRACT_PUBMED_23808545}}


==Function==
==The 1.9A crystal structure of humanized Xenopus MDM2 with RO5313109 - a pyrrolidine MDM2 inhibitor==
[[http://www.uniprot.org/uniprot/MDM2_XENLA MDM2_XENLA]] E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degration by the proteasome (By similarity).  
<StructureSection load='4jrg' size='340' side='right'caption='[[4jrg]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4jrg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JRG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JRG FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=I09:(3R,4R,5S)-3-(3-CHLOROPHENYL)-4-(4-CHLOROPHENYL)-4-CYANO-N-[(3S)-3,4-DIHYDROXYBUTYL]-5-(2,2-DIMETHYLPROPYL)-D-PROLINAMIDE'>I09</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jrg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jrg OCA], [https://pdbe.org/4jrg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jrg RCSB], [https://www.ebi.ac.uk/pdbsum/4jrg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jrg ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MDM2_XENLA MDM2_XENLA] E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degration by the proteasome (By similarity).


==About this Structure==
==See Also==
[[4jrg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JRG OCA].
*[[MDM2 3D structures|MDM2 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:023808545</ref><references group="xtra"/><references/>
[[Category: Large Structures]]
[[Category: Xenopus laevis]]
[[Category: Xenopus laevis]]
[[Category: Graves, B J.]]
[[Category: Graves BJ]]
[[Category: Janson, C A.]]
[[Category: Janson CA]]
[[Category: Lukacs, C.]]
[[Category: Lukacs C]]
[[Category: E3 ubiquitin ligase]]
[[Category: Ligase-ligase inhibitor complex]]
[[Category: Nucleus]]
[[Category: P53]]
[[Category: Protein-inhibitor complex]]
[[Category: Pyrrolidine]]
Retrieved from "https://proteopedia.org/4jrg"