4l02: Difference between revisions
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== | ==Crystal Structure of SphK1 with inhibitor== | ||
[[http://www.uniprot.org/uniprot/SPHK1_HUMAN SPHK1_HUMAN | <StructureSection load='4l02' size='340' side='right'caption='[[4l02]], [[Resolution|resolution]] 2.75Å' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4l02]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L02 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L02 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1V2:(2R,4S)-1-[2-(4-{[4-(3,4-DICHLOROPHENYL)-1,3-THIAZOL-2-YL]AMINO}PHENYL)ETHYL]-2-(HYDROXYMETHYL)PIPERIDIN-4-OL'>1V2</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l02 OCA], [https://pdbe.org/4l02 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l02 RCSB], [https://www.ebi.ac.uk/pdbsum/4l02 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l02 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/SPHK1_HUMAN SPHK1_HUMAN] Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol.<ref>PMID:20577214</ref> | |||
== | ==See Also== | ||
[[ | *[[Sphingosine kinase|Sphingosine kinase]] | ||
== References == | |||
== | <references/> | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Min | [[Category: Min X]] | ||
[[Category: Walker | [[Category: Walker N]] | ||
[[Category: Wang | [[Category: Wang Z]] | ||
Latest revision as of 12:16, 1 March 2024
Crystal Structure of SphK1 with inhibitor
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