2mb2: Difference between revisions
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New page: '''Unreleased structure''' The entry 2mb2 is ON HOLD Authors: Sengar, A., Heddi, B., Phan, A. Description: parallel-stranded G-quadruplex in DNA poly-G stretches |
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==parallel-stranded G-quadruplex in DNA poly-G stretches== | |||
<StructureSection load='2mb2' size='340' side='right'caption='[[2mb2]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2mb2]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MB2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MB2 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mb2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mb2 OCA], [https://pdbe.org/2mb2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mb2 RCSB], [https://www.ebi.ac.uk/pdbsum/2mb2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mb2 ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Poly-G sequences are found in different genomes including human and have the potential to form higher-order structures with various applications. Previously, long poly-G sequences were thought to lead to multiple possible ways of G-quadruplex folding, rendering their structural characterization challenging. Here we investigate the structure of G-quadruplexes formed by poly-G sequences d(TTGnT), where n = 12 to 19. Our data show the presence of multiple and/or higher-order G-quadruplex structures in most sequences. Strikingly, NMR spectra of the TTG15T sequence containing a stretch of 15 continuous guanines are exceptionally well-resolved and indicate the formation of a well-defined G-quadruplex structure. The NMR solution structure of this sequence revealed a propeller-type parallel-stranded G-quadruplex containing three G-tetrad layers and three single-guanine propeller loops. The same structure can potentially form anywhere along a long Gn stretch, making it unique for molecular recognition by other cellular molecules. | |||
Formation of G-Quadruplexes in Poly-G Sequences: Structure of a Propeller-Type Parallel-Stranded G-Quadruplex Formed by a G Stretch.,Sengar A, Heddi B, Phan AT Biochemistry. 2014 Dec 1. PMID:25375976<ref>PMID:25375976</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 2mb2" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Heddi B]] | |||
[[Category: Phan AT]] | |||
[[Category: Sengar A]] | |||
Latest revision as of 06:03, 15 May 2024
parallel-stranded G-quadruplex in DNA poly-G stretches
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