2mb3: Difference between revisions
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==Solution structure of an intramolecular (3+1) human telomeric G-quadruplex bound to a telomestatin derivative== | |||
<StructureSection load='2mb3' size='340' side='right'caption='[[2mb3]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2mb3]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MB3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MB3 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=L2H:(12S,27S)-12,27-BIS(4-AMINOBUTYL)-4,30-DIMETHYL-3,7,14,18,22,29-HEXAOXA-11,26,31,32,33,34,35,36-OCTAAZAHEPTACYCLO[26.2.1.1~2,5~.1~6,9~.1~13,16~.1~17,20~.1~21,24~]HEXATRIACONTA-1(30),2(36),4,6(35),8,13(34),15,17(33),19,21(32),23,28(31)-DODECAENE-10,25-DIONE'>L2H</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mb3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mb3 OCA], [https://pdbe.org/2mb3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mb3 RCSB], [https://www.ebi.ac.uk/pdbsum/2mb3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mb3 ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Guanine-rich human telomeric DNA can adopt secondary structures known as G-quadruplexes, which can be targeted by small molecules to achieve anticancer effects. So far, the structural information on complexes between human telomeric DNA and ligands is limited to the parallel G-quadruplex conformation, despite the high structural polymorphism of human telomeric G-quadruplexes. No structure has been yet resolved for the complex with telomestatin, one of the most promising G-quadruplex-targeting anticancer drug candidates. Here we present the first high-resolution structure of the complex between an intramolecular (3+1) human telomeric G-quadruplex and a telomestatin derivative, the macrocyclic hexaoxazole L2H2-6M(2)OTD. This compound is observed to interact with the G-quadruplex through pi-stacking and electrostatic interactions. This structural information provides a platform for the design of topology-specific G-quadruplex-targeting compounds and is valuable for the development of new potent anticancer drugs. | |||
Solution structure of an intramolecular (3+1) human telomeric G-quadruplex bound to a telomestatin derivative.,Chung WJ, Heddi B, Tera M, Iida K, Nagasawa K, Phan AT J Am Chem Soc. 2013 Aug 2. PMID:23909929<ref>PMID:23909929</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 2mb3" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Chung WJ]] | |||
[[Category: Heddi B]] | |||
[[Category: Iida K]] | |||
[[Category: Nagasawa K]] | |||
[[Category: Phan AT]] | |||
[[Category: Tera M]] | |||
Latest revision as of 06:03, 15 May 2024
Solution structure of an intramolecular (3+1) human telomeric G-quadruplex bound to a telomestatin derivative
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