4l9c: Difference between revisions
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==Crystal structure of the FP domain of human F-box protein Fbxo7 (native)== | |||
<StructureSection load='4l9c' size='340' side='right'caption='[[4l9c]], [[Resolution|resolution]] 2.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4l9c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L9C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L9C FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l9c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l9c OCA], [https://pdbe.org/4l9c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l9c RCSB], [https://www.ebi.ac.uk/pdbsum/4l9c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l9c ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/FBX7_HUMAN FBX7_HUMAN] Parkinsonian-pyramidal syndrome. The disease is caused by mutations affecting the gene represented in this entry. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/FBX7_HUMAN FBX7_HUMAN] Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5.<ref>PMID:15145941</ref> <ref>PMID:16510124</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Du Z]] | |||
[[Category: Huang X]] | |||
[[Category: Shang J]] | |||
[[Category: Wang G]] | |||
[[Category: Yang Y]] | |||
Latest revision as of 12:18, 1 March 2024
Crystal structure of the FP domain of human F-box protein Fbxo7 (native)
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