4ls0: Difference between revisions

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~~'''Unreleased structure'''~~

~~The~~ entry ~~4ls0~~ is ~~ON HOLD~~

==Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH01B0033==

== Structural highlights ==

<table><tr><td colspan='2'>[[4ls0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LS0 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=4LS0 FirstGlance].

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.07Å</td></tr>

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B3B:2-{(E)-[2-(4-PHENYL-1,3-THIAZOL-2-YL)HYDRAZINYLIDENE]METHYL}BENZALDEHYDE'>B3B</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=4ls0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ls0 OCA], [https://pdbe.org/4ls0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ls0 RCSB], [https://www.ebi.ac.uk/pdbsum/4ls0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ls0 ProSAT]</td></tr>

</table>

== Disease ==

[https://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN] Defects in DHODH are the cause of postaxial acrofacial dysostosis (POADS) [MIM:[https://omim.org/entry/263750 263750]; also known as Miller syndrome. POADS is characterized by severe micrognathia, cleft lip and/or palate, hypoplasia or aplasia of the posterior elements of the limbs, coloboma of the eyelids and supernumerary nipples. POADS is a very rare disorder: only 2 multiplex families, each consisting of 2 affected siblings born to unaffected, nonconsanguineous parents, have been described among a total of around 30 reported cases.<ref>PMID:19915526</ref>

== Function ==

[https://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.

~~Authors~~: ~~Zhu, L.,~~ Li, H~~. ,~~ Ren, X., Zhu, J.,

==See Also==

*[[Dihydroorotate dehydrogenase 3D structures|Dihydroorotate dehydrogenase 3D structures]]

~~Description~~: ~~Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH01B0033~~

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Li H]]

[[Category: Ren X]]

[[Category: Zhu J]]

[[Category: Zhu L]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 4ls0 is ON HOLD
+==Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH01B0033==
+<StructureSection load='4ls0' size='340' side='right'caption='[[4ls0]], [[Resolution|resolution]] 2.07&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4ls0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LS0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LS0 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.07&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B3B:2-{(E)-[2-(4-PHENYL-1,3-THIAZOL-2-YL)HYDRAZINYLIDENE]METHYL}BENZALDEHYDE'>B3B</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ls0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ls0 OCA], [https://pdbe.org/4ls0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ls0 RCSB], [https://www.ebi.ac.uk/pdbsum/4ls0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ls0 ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN] Defects in DHODH are the cause of postaxial acrofacial dysostosis (POADS) [MIM:[https://omim.org/entry/263750 263750]; also known as Miller syndrome. POADS is characterized by severe micrognathia, cleft lip and/or palate, hypoplasia or aplasia of the posterior elements of the limbs, coloboma of the eyelids and supernumerary nipples. POADS is a very rare disorder: only 2 multiplex families, each consisting of 2 affected siblings born to unaffected, nonconsanguineous parents, have been described among a total of around 30 reported cases.<ref>PMID:19915526</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
-Authors: Zhu, L., Li, H. , Ren, X., Zhu, J.,
+==See Also==
+*[[Dihydroorotate dehydrogenase 3D structures|Dihydroorotate dehydrogenase 3D structures]]
-Description: Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH01B0033
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Li H]]
+[[Category: Ren X]]
+[[Category: Zhu J]]
+[[Category: Zhu L]]