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{{STRUCTURE_4kxt|  PDB=4kxt  |  SCENE=  }}
===Structure of human ARGONAUTE1 in complex with guide RNA===
{{ABSTRACT_PUBMED_23809764}}


==Function==
==Structure of human ARGONAUTE1 in complex with guide RNA==
[[http://www.uniprot.org/uniprot/AGO1_HUMAN AGO1_HUMAN]] Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs).<ref>PMID:16289642</ref> <ref>PMID:16936728</ref> <ref>PMID:18771919</ref>
<StructureSection load='4kxt' size='340' side='right'caption='[[4kxt]], [[Resolution|resolution]] 2.29&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4kxt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Spodoptera_frugiperda Spodoptera frugiperda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KXT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KXT FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.294&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kxt OCA], [https://pdbe.org/4kxt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kxt RCSB], [https://www.ebi.ac.uk/pdbsum/4kxt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kxt ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/AGO1_HUMAN AGO1_HUMAN] Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs).<ref>PMID:16289642</ref> <ref>PMID:16936728</ref> <ref>PMID:18771919</ref>  


==About this Structure==
==See Also==
[[4kxt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Spodoptera_frugiperda Spodoptera frugiperda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KXT OCA].
*[[Argonaute 3D structures|Argonaute 3D structures]]
 
*[[Eukaryotic initiation factor 3D structures|Eukaryotic initiation factor 3D structures]]
==Reference==
== References ==
<ref group="xtra">PMID:023809764</ref><references group="xtra"/><references/>
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Spodoptera frugiperda]]
[[Category: Spodoptera frugiperda]]
[[Category: Nakanishi, K.]]
[[Category: Nakanishi K]]
[[Category: Patel, D J.]]
[[Category: Patel DJ]]
[[Category: Hydrolase-rna complex]]
[[Category: Nuclease]]
[[Category: Rna]]
[[Category: Rnase h fold]]
Retrieved from "https://proteopedia.org/4kxt"