4l5q: Difference between revisions

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{{STRUCTURE_4l5q|  PDB=4l5q  |  SCENE=  }}
===Crystal structure of p202 HIN1===
{{ABSTRACT_PUBMED_23850291}}


==Function==
==Crystal structure of p202 HIN1==
[[http://www.uniprot.org/uniprot/IFI2_MOUSE IFI2_MOUSE]] Inhibits the transcriptional activity of several transcription factors, including NF-kappa-B p50 and p65, FOS, JUN, E2F1, E2F4, MYOD1 and myogenin. Has anti-apoptotic effects due to inhibition of the transcriptional activity of p53. Binds dsDNA in the cytosol. Is involved in innate immune response and has anti-inflammatory activity. Inhibits caspase activation in response to cytosolic DNA and may inhibit the activation of the AIM2 inflammasome, probably via association with AIM2.<ref>PMID:16670293</ref> <ref>PMID:19131592</ref>
<StructureSection load='4l5q' size='340' side='right'caption='[[4l5q]], [[Resolution|resolution]] 2.23&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[4l5q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L5Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L5Q FirstGlance]. <br>
[[4l5q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L5Q OCA].
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.23&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l5q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l5q OCA], [https://pdbe.org/4l5q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l5q RCSB], [https://www.ebi.ac.uk/pdbsum/4l5q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l5q ProSAT]</span></td></tr>
==Reference==
</table>
<ref group="xtra">PMID:023850291</ref><references group="xtra"/><references/>
== Function ==
[https://www.uniprot.org/uniprot/IFI2_MOUSE IFI2_MOUSE] Inhibits the transcriptional activity of several transcription factors, including NF-kappa-B p50 and p65, FOS, JUN, E2F1, E2F4, MYOD1 and myogenin. Has anti-apoptotic effects due to inhibition of the transcriptional activity of p53. Binds dsDNA in the cytosol. Is involved in innate immune response and has anti-inflammatory activity. Inhibits caspase activation in response to cytosolic DNA and may inhibit the activation of the AIM2 inflammasome, probably via association with AIM2.<ref>PMID:16670293</ref> <ref>PMID:19131592</ref>  
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Tian, Y.]]
[[Category: Tian Y]]
[[Category: Wu, H.]]
[[Category: Wu H]]
[[Category: Yin, Q.]]
[[Category: Yin Q]]
[[Category: Dna binding protein]]
[[Category: Dsdna binding]]
[[Category: Hin200]]
[[Category: Tandem ob-fold]]
Retrieved from "https://proteopedia.org/4l5q"