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{{STRUCTURE_4ldq|  PDB=4ldq  |  SCENE=  }}
===Crystal Structure of the Mediator of Rho Dependent Invasion===
{{ABSTRACT_PUBMED_23859498}}


==Function==
==Crystal Structure of the Mediator of Rho Dependent Invasion==
[[http://www.uniprot.org/uniprot/MTNA_HUMAN MTNA_HUMAN]] Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Independently from catalytic activity, promotes cell invasion in response to constitutive RhoA activation by promoting FAK tyrosine phosphorylation and stress fiber turnover.<ref>PMID:19620624</ref>
<StructureSection load='4ldq' size='340' side='right'caption='[[4ldq]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[4ldq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LDQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LDQ FirstGlance]. <br>
[[4ldq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LDQ OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.496&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ldq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ldq OCA], [https://pdbe.org/4ldq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ldq RCSB], [https://www.ebi.ac.uk/pdbsum/4ldq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ldq ProSAT]</span></td></tr>
==Reference==
</table>
<ref group="xtra">PMID:023859498</ref><references group="xtra"/><references/>
== Function ==
[https://www.uniprot.org/uniprot/MTNA_HUMAN MTNA_HUMAN] Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Independently from catalytic activity, promotes cell invasion in response to constitutive RhoA activation by promoting FAK tyrosine phosphorylation and stress fiber turnover.<ref>PMID:19620624</ref>  
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: S-methyl-5-thioribose-1-phosphate isomerase]]
[[Category: Large Structures]]
[[Category: Metzner, S I.]]
[[Category: Metzner SI]]
[[Category: Sousa, M C.]]
[[Category: Sousa MC]]
[[Category: Templeton, P D.]]
[[Category: Templeton PD]]
[[Category: Cell invasion]]
[[Category: Helix bundle]]
[[Category: Isomerase]]
[[Category: Rossmann-like fold]]
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