Villin: Difference between revisions

[[Image:2k6n.png|left|thumb|300px|Crystal Strcture of the Human Supervillin Headpiece, [[2k6n]]]]

{{STRUCTURE_2k6n| right| PDB=2k6n  |  SCENE=Villin/Cv/1 |CAPTION=Human Supervillin Headpiece, [[2k6n]] }}

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

[[Villin]] (VIL) is an actin-binding protein.  It contains gelsolin-like domains in its N-terminal and a helical headpiece which binds actin<ref>PMID:10480879</ref>.  '''Supervillin (SVIL)''' contains numerous gelsolin-like domains in its C-terminal and interacts with actin.  '''Advillin (AVIL)''' is another actin-binding protein in the [[gelsolin]] superfamily which is expressed in the peripheral sensory neurons.  Cytovillin (CVIL) or ezrin serves as intermediate between plasma membrane and actin cytoskeleton. images on the left and right  correspond to one representative villin structure, ''i.e.'' the human supervillin headpiece ([[2k6n]]).

 

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=== Supervillin ===

[[2k6m]], [[2k6n]] – hSVIL headpiece– human – NMR<br />

=== Villin ===

[[3fg7]] – hVIL gelsolin domains 4-6<br />

[[2llf]] - hVIL gelsolin-like domain 6 - NMR<br />

[[1unc]] – hVIL headpiece<br />

[[3iur]] - hVIL headpiece H2H3 helices+prolyl endopeptidase – ''Aeromonas punctata''<br />

[[2rjw]], [[2rjx]], [[2rjv]], [[2rjy]], [[1yu7]], [[1yu8]] – cVIL headpiece (mutant) – chicken<br />

[[1yu5]], [[1qqv]] - cVIL headpiece<br />

[[3myc]], [[3mye]], [[3nkj]], [[3mya]], [[3tjw]], [[3trv]], [[3trw]], [[3try]] - cVIL headpiece (mutant)<br />

[[1vii]], [[2vik]], [[2vil]] - cVIL headpiece - NMR<br />

[[2ppz]], [[2jm0]] - VIL headpiece (mutant) – synthetic – NMR<br />

[[2f4k]], [[1wy3]], [[1wy4]], [[1yrf]], [[1yri]] - VIL fragment (mutant) – synthetic<br />

=== Advillin ===

[[1und]] – hAVIL headpiece<br />

===Cytovillin===

[[1ni2]] – hCVIL  N terminal<br />