4kg4: Difference between revisions

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'''Unreleased structure'''


The entry 4kg4 is ON HOLD  until Paper Publication
==Crystal structure of Saccharomyces cerevisiae Dcp2 Nudix domain (E198Q mutation)==
 
<StructureSection load='4kg4' size='340' side='right'caption='[[4kg4]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
Authors: Aglietti, R.A., Floor, S.N., Gross, J.D.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4kg4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KG4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KG4 FirstGlance]. <br>
Description: Crystal structure of Saccharomyces cerevisiae Dcp2 Nudix domain (E198Q mutation)
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kg4 OCA], [https://pdbe.org/4kg4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kg4 RCSB], [https://www.ebi.ac.uk/pdbsum/4kg4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kg4 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DCP2_YEAST DCP2_YEAST] Catalytic component of the decapping complex necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Decapping is the major pathway of mRNA degradation in yeast. It occurs through deadenylation, decapping and subsequent 5' to 3' exonucleolytic decay of the transcript body.<ref>PMID:10508173</ref> <ref>PMID:11139489</ref> <ref>PMID:11741542</ref> <ref>PMID:12554866</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae S288C]]
[[Category: Aglietti RA]]
[[Category: Floor SN]]
[[Category: Gross JD]]
Retrieved from "https://proteopedia.org/4kg4"