4j7d: Difference between revisions

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~~{{STRUCTURE_4j7d| PDB=4j7d | SCENE= }}~~

~~===The 1.25A crystal structure of humanized Xenopus MDM2 with a nutlin fragment, RO5045331===~~

~~{{ABSTRACT_PUBMED_14704432}}~~

==~~Function~~==

==The 1.25A crystal structure of humanized Xenopus MDM2 with a nutlin fragment, RO5045331==

[[http://www.uniprot.org/uniprot/MDM2_XENLA MDM2_XENLA]] E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degration by the proteasome (By similarity).

== Structural highlights ==

<table><tr><td colspan='2'>[[4j7d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J7D OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=4J7D FirstGlance].

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.25Å</td></tr>

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=I31:(4S,5R)-2-(4-TERT-BUTYL-2-ETHOXYPHENYL)-4,5-BIS(4-CHLOROPHENYL)-4,5-DIMETHYL-4,5-DIHYDRO-1H-IMIDAZOLE'>I31</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=4j7d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j7d OCA], [https://pdbe.org/4j7d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j7d RCSB], [https://www.ebi.ac.uk/pdbsum/4j7d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j7d ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/MDM2_XENLA MDM2_XENLA] E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degration by the proteasome (By similarity).

==~~About this Structure~~==

==See Also==

[[~~4j7d~~]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J7D OCA].

*[[MDM2 3D structures|MDM2 3D structures]]

__TOC__

~~==Reference==~~

</StructureSection>

<~~ref group="xtra"~~>~~PMID~~:~~014704432</ref><references group="xtra"/><references/>~~

[[Category: Large Structures]]

[[Category: Xenopus laevis]]

[[Category: Graves, B.]]

[[Category: Graves B]]

[[Category: Janson, C.]]

[[Category: Janson C]]

[[Category: Lukacs, C~~.]]~~

[[Category: Lukacs C]]

~~[[Category: E3 ubiquitin ligase]]~~

~~[[Category: Imidazoline]]~~

~~[[Category: Ligase-antagonist complex]]~~

~~[[Category: Nucleus]]~~

~~[[Category: P53]]~~

~~[[Category: Protein-protein interaction~~]]

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@@ Line 1: / Line 1: @@
-{{STRUCTURE_4j7d|  PDB=4j7d  |  SCENE=  }}
-===The 1.25A crystal structure of humanized Xenopus MDM2 with a nutlin fragment, RO5045331===
-{{ABSTRACT_PUBMED_14704432}}
-==Function==
+==The 1.25A crystal structure of humanized Xenopus MDM2 with a nutlin fragment, RO5045331==
-[[http://www.uniprot.org/uniprot/MDM2_XENLA MDM2_XENLA]] E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degration by the proteasome (By similarity).
+<StructureSection load='4j7d' size='340' side='right'caption='[[4j7d]], [[Resolution|resolution]] 1.25&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4j7d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J7D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J7D FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.25&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=I31:(4S,5R)-2-(4-TERT-BUTYL-2-ETHOXYPHENYL)-4,5-BIS(4-CHLOROPHENYL)-4,5-DIMETHYL-4,5-DIHYDRO-1H-IMIDAZOLE'>I31</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j7d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j7d OCA], [https://pdbe.org/4j7d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j7d RCSB], [https://www.ebi.ac.uk/pdbsum/4j7d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j7d ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/MDM2_XENLA MDM2_XENLA] E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degration by the proteasome (By similarity).
-==About this Structure==
+==See Also==
-[[4j7d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J7D OCA].
+*[[MDM2 3D structures|MDM2 3D structures]]
+__TOC__
-==Reference==
+</StructureSection>
-<ref group="xtra">PMID:014704432</ref><references group="xtra"/><references/>
+[[Category: Large Structures]]
 [[Category: Xenopus laevis]]
-[[Category: Graves, B.]]
+[[Category: Graves B]]
-[[Category: Janson, C.]]
+[[Category: Janson C]]
-[[Category: Lukacs, C.]]
+[[Category: Lukacs C]]
-[[Category: E3 ubiquitin ligase]]
-[[Category: Imidazoline]]
-[[Category: Ligase-antagonist complex]]
-[[Category: Nucleus]]
-[[Category: P53]]
-[[Category: Protein-protein interaction]]