4fqs: Difference between revisions

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~~{{STRUCTURE_4fqs| PDB=4fqs | SCENE= }}~~

~~===Crystal Structure of Mycobacterium tuberculosis ThyA in complex with UMP and Pemetrexed===~~

==~~Function~~==

==Crystal Structure of Mycobacterium tuberculosis ThyA in complex with UMP and Pemetrexed==

[[http://www.uniprot.org/uniprot/TYSY_MYCTU TYSY_MYCTU]] Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity).

== Structural highlights ==

<table><tr><td colspan='2'>[[4fqs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FQS OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=4FQS FirstGlance].

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr>

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LYA:2-{4-[2-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)-ETHYL]-BENZOYLAMINO}-PENTANEDIOIC+ACID'>LYA</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=4fqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fqs OCA], [https://pdbe.org/4fqs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fqs RCSB], [https://www.ebi.ac.uk/pdbsum/4fqs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fqs ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/TYSY_MYCTU TYSY_MYCTU] Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity).

==~~About this Structure~~==

==See Also==

[[~~4fqs~~]] ~~is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki~~/~~Mycobacterium_tuberculosis_h37rv Mycobacterium tuberculosis h37rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FQS OCA].~~

*[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]]

[[Category: ~~Mycobacterium tuberculosis h37rv~~]]

__TOC__

[[Category: ~~Thymidylate synthase~~]]

</StructureSection>

[[Category: Bruning~~, J B.~~]]

[[Category: Large Structures]]

[[Category: Harshbarger, W.]]

[[Category: Mycobacterium tuberculosis H37Rv]]

[[Category: Reddy~~, M C.M.~~]]

[[Category: Bruning JB]]

[[Category: Sacchettini~~, J C.]]~~

[[Category: Harshbarger W]]

~~[[Category: Folate binding]]~~

[[Category: Reddy MCM]]

~~[[Category: Transferase]]~~

[[Category: Sacchettini JC]]

~~[[Category: Transferase-transferase inhibitor complex~~]]

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@@ Line 1: / Line 1: @@
-{{STRUCTURE_4fqs|  PDB=4fqs  |  SCENE=  }}
-===Crystal Structure of Mycobacterium tuberculosis ThyA in complex with UMP and Pemetrexed===
-==Function==
+==Crystal Structure of Mycobacterium tuberculosis ThyA in complex with UMP and Pemetrexed==
-[[http://www.uniprot.org/uniprot/TYSY_MYCTU TYSY_MYCTU]] Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity).
+<StructureSection load='4fqs' size='340' side='right'caption='[[4fqs]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4fqs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FQS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FQS FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LYA:2-{4-[2-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)-ETHYL]-BENZOYLAMINO}-PENTANEDIOIC+ACID'>LYA</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fqs OCA], [https://pdbe.org/4fqs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fqs RCSB], [https://www.ebi.ac.uk/pdbsum/4fqs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fqs ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/TYSY_MYCTU TYSY_MYCTU] Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity).
-==About this Structure==
+==See Also==
-[[4fqs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_h37rv Mycobacterium tuberculosis h37rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FQS OCA].
+*[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]]
-[[Category: Mycobacterium tuberculosis h37rv]]
+__TOC__
-[[Category: Thymidylate synthase]]
+</StructureSection>
-[[Category: Bruning, J B.]]
+[[Category: Large Structures]]
-[[Category: Harshbarger, W.]]
+[[Category: Mycobacterium tuberculosis H37Rv]]
-[[Category: Reddy, M C.M.]]
+[[Category: Bruning JB]]
-[[Category: Sacchettini, J C.]]
+[[Category: Harshbarger W]]
-[[Category: Folate binding]]
+[[Category: Reddy MCM]]
-[[Category: Transferase]]
+[[Category: Sacchettini JC]]
-[[Category: Transferase-transferase inhibitor complex]]