4lrg: Difference between revisions
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== | ==Structure of BRD4 bromodomain 1 with a dimethyl thiophene isoxazole azepine carboxamide== | ||
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN | <StructureSection load='4lrg' size='340' side='right'caption='[[4lrg]], [[Resolution|resolution]] 2.21Å' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4lrg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LRG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LRG FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.21Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1XB:2-[(6S)-4-(4-CHLOROPHENYL)-2,3,9-TRIMETHYL-6H-[1,2]OXAZOLO[5,4-C]THIENO[2,3-E]AZEPIN-6-YL]ACETAMIDE'>1XB</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lrg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lrg OCA], [https://pdbe.org/4lrg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lrg RCSB], [https://www.ebi.ac.uk/pdbsum/4lrg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lrg ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | |||
== | ==See Also== | ||
[[ | *[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]] | ||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
== | |||
<references | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Albrecht | [[Category: Large Structures]] | ||
[[Category: Audia | [[Category: Albrecht B]] | ||
[[Category: Bellon | [[Category: Audia J]] | ||
[[Category: Bergeron | [[Category: Bellon S]] | ||
[[Category: Birudukota | [[Category: Bergeron L]] | ||
[[Category: Bryant | [[Category: Birudukota S]] | ||
[[Category: Cote | [[Category: Bryant B]] | ||
[[Category: Gehling | [[Category: Cote A]] | ||
[[Category: Harmange | [[Category: Gehling V]] | ||
[[Category: Hewitt | [[Category: Harmange J-C]] | ||
[[Category: Jayaram | [[Category: Hewitt M]] | ||
[[Category: Joshi | [[Category: Jayaram H]] | ||
[[Category: Leblanc | [[Category: Joshi S]] | ||
[[Category: Mertz | [[Category: Leblanc Y]] | ||
[[Category: Nandana | [[Category: Mertz J]] | ||
[[Category: Nasveschuk | [[Category: Nandana BS]] | ||
[[Category: Pardo | [[Category: Nasveschuk C]] | ||
[[Category: Poy | [[Category: Pardo E]] | ||
[[Category: | [[Category: Poy F]] | ||
[[Category: | [[Category: Ravichandran S]] | ||
[[Category: Sims | [[Category: Sandy P]] | ||
[[Category: Taylor | [[Category: Sims R]] | ||
[[Category: Vaswani | [[Category: Taylor A]] | ||
[[Category: Yellapuntala | [[Category: Vaswani R]] | ||
[[Category: Yellapuntala S]] | |||
Latest revision as of 12:21, 1 March 2024
Structure of BRD4 bromodomain 1 with a dimethyl thiophene isoxazole azepine carboxamide
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