4m3e: Difference between revisions
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==Rapid and efficient design of new inhibitors of Mycobacterium tuberculosis transcriptional repressor EthR using fragment growing, merging and linking approaches== | |||
<StructureSection load='4m3e' size='340' side='right'caption='[[4m3e]], [[Resolution|resolution]] 2.11Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4m3e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M3E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M3E FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.109Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2B3:4-(2-{[(PROPYLSULFONYL)AMINO]METHYL}-1,3-THIAZOL-4-YL)-N-(3,3,3-TRIFLUOROPROPYL)BENZAMIDE'>2B3</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m3e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m3e OCA], [https://pdbe.org/4m3e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m3e RCSB], [https://www.ebi.ac.uk/pdbsum/4m3e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m3e ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/ETHR_MYCTU ETHR_MYCTU] Involved in the repression of the monooxygenase EthA which is responsible of the formation of the active metabolite of ethionamide (ETH).<ref>PMID:10869356</ref> <ref>PMID:10944230</ref> | |||
==See Also== | |||
*[[Tetracycline repressor protein 3D structures|Tetracycline repressor protein 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mycobacterium tuberculosis H37Rv]] | |||
[[Category: Baulard A]] | |||
[[Category: Blondiaux N]] | |||
[[Category: Brodin P]] | |||
[[Category: Crauste C]] | |||
[[Category: Deprez B]] | |||
[[Category: Flipo M]] | |||
[[Category: Leroux F]] | |||
[[Category: Malaquin S]] | |||
[[Category: Piveteau C]] | |||
[[Category: Sperandio O]] | |||
[[Category: Villemagne B]] | |||
[[Category: Villeret V]] | |||
[[Category: Villoutreix B]] | |||
[[Category: Willand N]] | |||
[[Category: Wintjens R]] | |||
[[Category: Wohlkonig A]] | |||
Latest revision as of 12:23, 1 March 2024
Rapid and efficient design of new inhibitors of Mycobacterium tuberculosis transcriptional repressor EthR using fragment growing, merging and linking approaches
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