4m5s: Difference between revisions
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New page: '''Unreleased structure''' The entry 4m5s is ON HOLD Authors: Laganowsky, Arthur, Cascio, Duilio, Sawaya, Michael R., Eisenberg, David Description: Human alphaB crystallin core domain ... |
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The entry | ==Human alphaB crystallin core domain in complex with C-terminal peptide== | ||
<StructureSection load='4m5s' size='340' side='right'caption='[[4m5s]], [[Resolution|resolution]] 1.37Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4m5s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M5S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M5S FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.37Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SIN:SUCCINIC+ACID'>SIN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m5s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m5s OCA], [https://pdbe.org/4m5s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m5s RCSB], [https://www.ebi.ac.uk/pdbsum/4m5s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m5s ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/CRYAB_HUMAN CRYAB_HUMAN] Posterior polar cataract;Alpha-crystallinopathy;Zonular cataract;Familial isolated dilated cardiomyopathy;Fatal infantile hypertonic myofibrillar myopathy. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/CRYAB_HUMAN CRYAB_HUMAN] May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. | |||
==See Also== | |||
*[[Crystallin 3D structures|Crystallin 3D structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Cascio D]] | |||
[[Category: Eisenberg D]] | |||
[[Category: Laganowsky A]] | |||
[[Category: Sawaya MR]] | |||
Latest revision as of 12:24, 1 March 2024
Human alphaB crystallin core domain in complex with C-terminal peptide
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