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{{STRUCTURE_2m85|  PDB=2m85  |  SCENE=  }}
===PHD Domain from Human SHPRH===


==Function==
==PHD Domain from Human SHPRH==
[[http://www.uniprot.org/uniprot/SHPRH_HUMAN SHPRH_HUMAN]] E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'.<ref>PMID:17130289</ref> <ref>PMID:17108083</ref> <ref>PMID:18719106</ref>
<StructureSection load='2m85' size='340' side='right'caption='[[2m85]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2m85]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M85 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M85 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m85 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m85 OCA], [https://pdbe.org/2m85 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m85 RCSB], [https://www.ebi.ac.uk/pdbsum/2m85 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m85 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SHPRH_HUMAN SHPRH_HUMAN] E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'.<ref>PMID:17130289</ref> <ref>PMID:17108083</ref> <ref>PMID:18719106</ref>  


==About this Structure==
==See Also==
[[2m85]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M85 OCA].
*[[Exosome 3D structures|Exosome 3D structures]]
 
*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]
==Reference==
== References ==
<ref group="xtra">PMID:023907177</ref><references group="xtra"/><references/>
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Almeida, F C.L.]]
[[Category: Large Structures]]
[[Category: Bezsonova, I.]]
[[Category: Almeida FCL]]
[[Category: Korzhnev, D M.]]
[[Category: Bezsonova I]]
[[Category: Machado, L E.S F.]]
[[Category: Korzhnev DM]]
[[Category: Pozhidaeva, A.]]
[[Category: Machado LESF]]
[[Category: Pustovalova, Y.]]
[[Category: Pozhidaeva A]]
[[Category: Helicase]]
[[Category: Pustovalova Y]]
[[Category: Histone linker]]
[[Category: Hydrolase]]
[[Category: Ligase]]
[[Category: Phd finger]]
[[Category: Ring finger]]
[[Category: Shprh]]
[[Category: Snf2]]
Retrieved from "https://proteopedia.org/2m85"