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{{STRUCTURE_4jyk|  PDB=4jyk  |  SCENE=  }}
===Structure of E. coli Transcriptional Regulator RutR with bound uracil===


==Function==
==Structure of E. coli Transcriptional Regulator RutR with bound uracil==
[[http://www.uniprot.org/uniprot/RUTR_ECOLI RUTR_ECOLI]] Master transcription regulator which represses the degradation of pyrimidines (rutABCDEFG) and purines (gcl operon) for maintenance of metabolic balance between pyrimidines and purines. It also regulates the synthesis of pyrimidine nucleotides and arginine from glutamine (carAB) and the supply of glutamate (gadABWX).<ref>PMID:16540542</ref> <ref>PMID:17919280</ref>
<StructureSection load='4jyk' size='340' side='right'caption='[[4jyk]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4jyk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JYK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JYK FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=URA:URACIL'>URA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jyk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jyk OCA], [https://pdbe.org/4jyk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jyk RCSB], [https://www.ebi.ac.uk/pdbsum/4jyk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jyk ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RUTR_ECOLI RUTR_ECOLI] Master transcription regulator which represses the degradation of pyrimidines (rutABCDEFG) and purines (gcl operon) for maintenance of metabolic balance between pyrimidines and purines. It also regulates the synthesis of pyrimidine nucleotides and arginine from glutamine (carAB) and the supply of glutamate (gadABWX).<ref>PMID:16540542</ref> <ref>PMID:17919280</ref>  


==About this Structure==
==See Also==
[[4jyk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JYK OCA].
*[[Tetracycline repressor protein 3D structures|Tetracycline repressor protein 3D structures]]
 
*[[Transcriptional activator 3D structures|Transcriptional activator 3D structures]]
==Reference==
== References ==
<references group="xtra"/><references/>
<references/>
[[Category: Escherichia coli k-12]]
__TOC__
[[Category: Almo, S C.]]
</StructureSection>
[[Category: Cooper, D R.]]
[[Category: Escherichia coli K-12]]
[[Category: Knapik, A A.]]
[[Category: Large Structures]]
[[Category: Minor, W.]]
[[Category: Almo SC]]
[[Category: NYSGRC, New York Structural Genomics Research Consortium.]]
[[Category: Cooper DR]]
[[Category: Osinski,T.]]
[[Category: Knapik AA]]
[[Category: Petkowski, J J.]]
[[Category: Minor W]]
[[Category: Porebski, P J.]]
[[Category: Osinski T]]
[[Category: Helix-turn-helix]]
[[Category: Petkowski JJ]]
[[Category: New york structural genomics research consortium]]
[[Category: Porebski PJ]]
[[Category: Nysgrc]]
[[Category: Psi-biology]]
[[Category: Structural genomic]]
[[Category: Transcription regulator]]
[[Category: Transcriptional regulator]]
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