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'''Unreleased structure'''


The entry 4c1i is ON HOLD  until Paper Publication
==Selective Inhibitors of PDE2, PDE9, and PDE10: Modulators of Activity of the Central Nervous System==
<StructureSection load='4c1i' size='340' side='right'caption='[[4c1i]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4c1i]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C1I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C1I FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EH9:(2S,3R)-3-(6-AMINO-9H-PURIN-9-YL)NONAN-2-OL'>EH9</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c1i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c1i OCA], [https://pdbe.org/4c1i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c1i RCSB], [https://www.ebi.ac.uk/pdbsum/4c1i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c1i ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PDE2A_HUMAN PDE2A_HUMAN] Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes.<ref>PMID:15938621</ref> <ref>PMID:19828435</ref>


Authors: Jorgensen, M., Kehler, J., Langgard, M., Svenstrup, N., Tagmose, L.
==See Also==
 
*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
Description: Selective Inhibitors of PDE2, PDE9, and PDE10: Modulators of Activity of the Central Nervous System
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Jorgensen M]]
[[Category: Kehler J]]
[[Category: Langgard M]]
[[Category: Svenstrup N]]
[[Category: Tagmose L]]
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