4m6r: Difference between revisions
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New page: '''Unreleased structure''' The entry 4m6r is ON HOLD Authors: Kang, W., Hong, S.H., Lee, H.M., Kim, N.Y., Lim, Y.C., Le, L.T.M., Kim, H.C., Kim, T.Y., Ashida, H., Yokota, A., Hah, S.S.,... |
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==Structural and biochemical basis for the inhibition of cell death by APIP, a methionine salvage enzyme== | |||
<StructureSection load='4m6r' size='340' side='right'caption='[[4m6r]], [[Resolution|resolution]] 2.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4m6r]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M6R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M6R FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m6r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m6r OCA], [https://pdbe.org/4m6r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m6r RCSB], [https://www.ebi.ac.uk/pdbsum/4m6r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m6r ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/MTNB_HUMAN MTNB_HUMAN] Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death.<ref>PMID:15262985</ref> <ref>PMID:23285211</ref> <ref>PMID:22837397</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Ashida H]] | |||
[[Category: Chun KH]] | |||
[[Category: Hah SS]] | |||
[[Category: Hong SH]] | |||
[[Category: Jung YK]] | |||
[[Category: Kang W]] | |||
[[Category: Kim HC]] | |||
[[Category: Kim NY]] | |||
[[Category: Kim TY]] | |||
[[Category: Le LTM]] | |||
[[Category: Lee HM]] | |||
[[Category: Lim B]] | |||
[[Category: Lim YC]] | |||
[[Category: Yang JK]] | |||
[[Category: Yokota A]] | |||
Latest revision as of 08:55, 20 March 2024
Structural and biochemical basis for the inhibition of cell death by APIP, a methionine salvage enzyme
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