4m7i: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry 4m7i is ON HOLD~~

==Crystal Structure of GSK6157 Bound to PERK (R587-R1092, delete A660-T867) at 2.34A Resolution==

~~Authors: Gampe RT, Axten JM~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4m7i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M7I OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=4M7I FirstGlance].

~~Description:~~ Crystal Structure of GSK6157 Bound to PERK (R587-R1092, delete A660-T867)@2.34A Resolution

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.34Å</td></tr>

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=27D:1-[5-(4-AMINO-7-METHYL-7H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)-4-FLUORO-1H-INDOL-1-YL]-2-(6-METHYLPYRIDIN-2-YL)ETHANONE'>27D</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=4m7i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m7i OCA], [https://pdbe.org/4m7i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m7i RCSB], [https://www.ebi.ac.uk/pdbsum/4m7i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m7i ProSAT]</td></tr>

</table>

== Disease ==

[https://www.uniprot.org/uniprot/E2AK3_HUMAN E2AK3_HUMAN] Wolcott-Rallison syndrome. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:10932183</ref>

== Function ==

[https://www.uniprot.org/uniprot/E2AK3_HUMAN E2AK3_HUMAN] Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1) (By similarity).

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Axten JM]]

[[Category: Gampe RT]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 4m7i is ON HOLD
+==Crystal Structure of GSK6157 Bound to PERK (R587-R1092, delete A660-T867) at 2.34A Resolution==
+<StructureSection load='4m7i' size='340' side='right'caption='[[4m7i]], [[Resolution|resolution]] 2.34&Aring;' scene=''>
-Authors: Gampe RT, Axten JM
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4m7i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M7I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M7I FirstGlance]. <br>
-Description: Crystal Structure of GSK6157 Bound to PERK (R587-R1092, delete A660-T867)@2.34A Resolution
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.34&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=27D:1-[5-(4-AMINO-7-METHYL-7H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)-4-FLUORO-1H-INDOL-1-YL]-2-(6-METHYLPYRIDIN-2-YL)ETHANONE'>27D</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m7i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m7i OCA], [https://pdbe.org/4m7i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m7i RCSB], [https://www.ebi.ac.uk/pdbsum/4m7i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m7i ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/E2AK3_HUMAN E2AK3_HUMAN] Wolcott-Rallison syndrome. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:10932183</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/E2AK3_HUMAN E2AK3_HUMAN] Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1) (By similarity).
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Axten JM]]
+[[Category: Gampe RT]]