4m7l: Difference between revisions
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==Crystal structure of the complex between human tissue factor extracellular domain and antibody 10H10 FAB fragment== | |||
<StructureSection load='4m7l' size='340' side='right'caption='[[4m7l]], [[Resolution|resolution]] 3.40Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4m7l]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M7L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M7L FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.4Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m7l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m7l OCA], [https://pdbe.org/4m7l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m7l RCSB], [https://www.ebi.ac.uk/pdbsum/4m7l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m7l ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/TF_HUMAN TF_HUMAN] Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.<ref>PMID:12652293</ref> | |||
==See Also== | |||
*[[Tissue factor|Tissue factor]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | |||
[[Category: Gilliland GL]] | |||
[[Category: Malia T]] | |||
[[Category: Obmolova G]] | |||
[[Category: Teplyakov A]] | |||
Latest revision as of 16:33, 20 September 2023
Crystal structure of the complex between human tissue factor extracellular domain and antibody 10H10 FAB fragment
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