4l5n: Difference between revisions
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== | ==Crystallographic Structure of HHV-1 Uracil-DNA Glycosylase complexed with the Bacillus phage PZA inhibitor protein p56== | ||
[[http://www.uniprot.org/uniprot/UNG_HHV11 UNG_HHV11 | <StructureSection load='4l5n' size='340' side='right'caption='[[4l5n]], [[Resolution|resolution]] 2.16Å' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4l5n]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_phage_PZA Bacillus phage PZA] and [https://en.wikipedia.org/wiki/Human_alphaherpesvirus_1_strain_17 Human alphaherpesvirus 1 strain 17]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L5N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L5N FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.16Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l5n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l5n OCA], [https://pdbe.org/4l5n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l5n RCSB], [https://www.ebi.ac.uk/pdbsum/4l5n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l5n ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/UNG_HHV11 UNG_HHV11] Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or deamination of cytosine. Therefore may reduce deleterious uracil incorporation into the viral genome, particularly, in terminally differentiated neurons which lack DNA repair enzymes.<ref>PMID:7552746</ref> <ref>PMID:16306042</ref> | |||
== | ==See Also== | ||
[[ | *[[DNA glycosylase 3D structures|DNA glycosylase 3D structures]] | ||
== References == | |||
== | <references/> | ||
__TOC__ | |||
[[Category: Bacillus phage | </StructureSection> | ||
[[Category: | [[Category: Bacillus phage PZA]] | ||
[[Category: Baltulionis | [[Category: Human alphaherpesvirus 1 strain 17]] | ||
[[Category: Cole | [[Category: Large Structures]] | ||
[[Category: Hornyak | [[Category: Baltulionis G]] | ||
[[Category: Ryzhenkova | [[Category: Cole AR]] | ||
[[Category: Sapir | [[Category: Hornyak P]] | ||
[[Category: Savva | [[Category: Ryzhenkova K]] | ||
[[Category: Sapir O]] | |||
[[Category: Savva R]] | |||
Latest revision as of 12:17, 1 March 2024
Crystallographic Structure of HHV-1 Uracil-DNA Glycosylase complexed with the Bacillus phage PZA inhibitor protein p56
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