F-actin: Difference between revisions
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<StructureSection load='2zwh' size=' | <StructureSection load='2zwh' size='350' side='right' scene='' caption='Rabbit α-actin complex with ADP and Ca+2 ion (PDB code [[2zwh]])'> | ||
[[Image:2zwh.png|left|200px|thumb|Crystal Structure of F-actin, [[2zwh]]]]'''Filamentous actin''' ('''F-actin''') units are also referred to as [http://en.wikipedia.org/wiki/microfilament microfilaments] <ref> Microfilaments - Wikipedia, the free encyclopedia. http://en.wikipedia.org/wiki/Microfilament. Date accessed: March 16th, 2010. </ref> and are highly conserved, proteinous components found near ubiquitously in eukaryotic cytoskeletons. F-actin and other [[actin]] proteins generally have structural roles in cells. | [[Image:2zwh.png|left|200px|thumb|Crystal Structure of F-actin, [[2zwh]]]]'''Filamentous actin''' ('''F-actin''') units are also referred to as [http://en.wikipedia.org/wiki/microfilament microfilaments] <ref> Microfilaments - Wikipedia, the free encyclopedia. http://en.wikipedia.org/wiki/Microfilament. Date accessed: March 16th, 2010. </ref> and are highly conserved, proteinous components found near ubiquitously in eukaryotic cytoskeletons. F-actin and other [[actin]] proteins generally have structural roles in cells. | ||
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==== [http://en.wikipedia.org/wiki/Actin#Actomyosin_filaments Actin-Myosin] ==== | ==== [http://en.wikipedia.org/wiki/Actin#Actomyosin_filaments Actin-Myosin] ==== | ||
The relatively flatter shape of F-actin as compared to G-actin allows myosin to preferentially bind F-actin over G-actin. This means that F-actin, not G-actin, is the functional form of actin. It composes a large part of the thin filaments in conjunction with mysoin to give muscle contractions<ref name="Holmes2"/><ref name="Holmes3>PMID:14508495</ref>. The structure of F-actin gives it large resistance to extensive forces, such as those experienced in muscle contraction<ref name="Mitchinson"/>. | The relatively flatter shape of F-actin as compared to G-actin allows myosin to preferentially bind F-actin over G-actin. This means that F-actin, not G-actin, is the functional form of actin. It composes a large part of the thin filaments in conjunction with mysoin to give muscle contractions<ref name="Holmes2"/><ref name="Holmes3>PMID:14508495</ref>. The structure of F-actin gives it large resistance to extensive forces, such as those experienced in muscle contraction<ref name="Mitchinson"/>. | ||
</StructureSection> | |||
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==3D structures of actin== | ==3D structures of actin== | ||
