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{{STRUCTURE_4ffb|  PDB=4ffb  |  SCENE=  }}
===A TOG:alpha/beta-tubulin Complex Structure Reveals Conformation-Based Mechanisms For a Microtubule Polymerase===
{{ABSTRACT_PUBMED_22904013}}


==Function==
==A TOG:alpha/beta-tubulin Complex Structure Reveals Conformation-Based Mechanisms For a Microtubule Polymerase==
[[http://www.uniprot.org/uniprot/TBA1_YEAST TBA1_YEAST]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [[http://www.uniprot.org/uniprot/STU2_YEAST STU2_YEAST]] May play a role in the attachment, organization, and/or dynamics of microtubule ends at the spindle pole body. [[http://www.uniprot.org/uniprot/TBB_YEAST TBB_YEAST]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
<StructureSection load='4ffb' size='340' side='right'caption='[[4ffb]], [[Resolution|resolution]] 2.88&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[4ffb]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FFB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FFB FirstGlance]. <br>
[[4ffb]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FFB OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.882&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ffb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ffb OCA], [https://pdbe.org/4ffb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ffb RCSB], [https://www.ebi.ac.uk/pdbsum/4ffb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ffb ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TBA1_YEAST TBA1_YEAST] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.


==See Also==
==See Also==
*[[Tubulin|Tubulin]]
*[[Tubulin 3D Structures|Tubulin 3D Structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:022904013</ref><references group="xtra"/><references/>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae s288c]]
[[Category: Saccharomyces cerevisiae S288C]]
[[Category: Tubulin GTPase]]
[[Category: Ayaz P]]
[[Category: Ayaz, P.]]
[[Category: Brautigam CA]]
[[Category: Brautigam, C A.]]
[[Category: Huddleston P]]
[[Category: Huddleston, P.]]
[[Category: Rice LM]]
[[Category: Rice, L M.]]
[[Category: Ye X]]
[[Category: Ye, X.]]
[[Category: Cytoskeleton]]
[[Category: Heat repeat]]
[[Category: Hydrolase]]
[[Category: Microtubule]]
[[Category: Tog domain]]
[[Category: Tubulin]]
[[Category: Tubulin fold]]
Retrieved from "https://proteopedia.org/4ffb"