4f2j: Difference between revisions

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{{STRUCTURE_4f2j|  PDB=4f2j  |  SCENE=  }}
===Crystal structure of ZNF217 bound to DNA, P6522 crystal form===
{{ABSTRACT_PUBMED_23436653}}


==Function==
==Crystal structure of ZNF217 bound to DNA, P6522 crystal form==
[[http://www.uniprot.org/uniprot/ZN217_HUMAN ZN217_HUMAN]] Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'.<ref>PMID:16203743</ref> <ref>PMID:17259635</ref> <ref>PMID:18625718</ref> <ref>PMID:16940172</ref>
<StructureSection load='4f2j' size='340' side='right'caption='[[4f2j]], [[Resolution|resolution]] 2.64&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[4f2j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F2J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4F2J FirstGlance]. <br>
[[4f2j]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F2J OCA].
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.64&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
==Reference==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4f2j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f2j OCA], [https://pdbe.org/4f2j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4f2j RCSB], [https://www.ebi.ac.uk/pdbsum/4f2j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4f2j ProSAT]</span></td></tr>
<ref group="xtra">PMID:023436653</ref><references group="xtra"/><references/>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ZN217_HUMAN ZN217_HUMAN] Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'.<ref>PMID:16203743</ref> <ref>PMID:17259635</ref> <ref>PMID:18625718</ref> <ref>PMID:16940172</ref>  
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Guss, J M.]]
[[Category: Large Structures]]
[[Category: Jacques, D A.]]
[[Category: Guss JM]]
[[Category: Mackay, J P.]]
[[Category: Jacques DA]]
[[Category: Vandevenne, M S.]]
[[Category: Mackay JP]]
[[Category: Dna binding]]
[[Category: Vandevenne MS]]
[[Category: Metal binding protein-dna complex]]
[[Category: Nucleus]]
[[Category: Transcription factor]]
[[Category: Zinc finger]]
Retrieved from "https://proteopedia.org/4f2j"