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[[Image:2nti.jpg|left|200px]]<br /><applet load="2nti" size="350" color="white" frame="true" align="right" spinBox="true"
caption="2nti, resolution 2.50&Aring;" />
'''Crystal structure of PCNA123 heterotrimer.'''<br />


==About this Structure==
==Crystal structure of PCNA123 heterotrimer.==
2NTI is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus] with <scene name='pdbligand=BR:'>BR</scene>, <scene name='pdbligand=K:'>K</scene> and <scene name='pdbligand=7PG:'>7PG</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NTI OCA].
<StructureSection load='2nti' size='340' side='right'caption='[[2nti]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
[[Category: Protein complex]]
== Structural highlights ==
[[Category: Sulfolobus solfataricus]]
<table><tr><td colspan='2'>[[2nti]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus_P2 Saccharolobus solfataricus P2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NTI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NTI FirstGlance]. <br>
[[Category: Hlinkova, V.]]
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
[[Category: Ling, H.]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7PG:2,5,8,11,14,17,20,23-OCTAOXAPENTACOSAN-25-OL'>7PG</scene>, <scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
[[Category: 7PG]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nti FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nti OCA], [https://pdbe.org/2nti PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nti RCSB], [https://www.ebi.ac.uk/pdbsum/2nti PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nti ProSAT]</span></td></tr>
[[Category: BR]]
</table>
[[Category: K]]
== Function ==
[[Category: dna binding protein]]
[https://www.uniprot.org/uniprot/PCNA1_SACS2 PCNA1_SACS2] One of the sliding clamp subunits that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication. Heterotrimer stimulates the Holliday junction resolvase Hjc. DNA polymerase I, DNA ligase and the flap endonuclease may be constitutively associated with the PCNA heterotrimer forming a scanning complex able to couple DNA synthesis and Okazaki fragment maturation.<ref>PMID:12535540</ref> <ref>PMID:17011573</ref>
[[Category: pcna12 heterodimer]]
== Evolutionary Conservation ==
[[Category: pcna123 heterotrimer]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: protein-protein interaction]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nt/2nti_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2nti ConSurf].
<div style="clear:both"></div>


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:10:49 2008''
==See Also==
*[[Proliferating cell nuclear antigen 3D structures|Proliferating cell nuclear antigen 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharolobus solfataricus P2]]
[[Category: Hlinkova V]]
[[Category: Ling H]]
Retrieved from "https://proteopedia.org/2nti"