4mdx: Difference between revisions
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New page: '''Unreleased structure''' The entry 4mdx is ON HOLD Authors: Simanshu, D.K., Patel, D.J. Description: Crystal structure of Bacillus subtilis MazF in complex with RNA |
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==Crystal structure of Bacillus subtilis MazF in complex with RNA== | |||
<StructureSection load='4mdx' size='340' side='right'caption='[[4mdx]], [[Resolution|resolution]] 1.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4mdx]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis_subsp._subtilis_str._168 Bacillus subtilis subsp. subtilis str. 168]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MDX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MDX FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mdx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mdx OCA], [https://pdbe.org/4mdx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mdx RCSB], [https://www.ebi.ac.uk/pdbsum/4mdx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mdx ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/ENDOA_BACSU ENDOA_BACSU] Toxic component of a toxin-antitoxin (TA) module. Has specificity for UACAU sequences, claving after the first U and yielding cleavage products with 3' phosphate and 5' hydroxyl groups. Overexpression is toxic for cell growth, probably by inhibiting protein synthesis through the cleavage of single-stranded RNA. The toxicity is reversed by the antitoxin EndoAI. Toxin activity cannot be inhibited by MazE from E.coli.<ref>PMID:15882409</ref> <ref>PMID:21763692</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Bacillus subtilis subsp. subtilis str. 168]] | |||
[[Category: Large Structures]] | |||
[[Category: Patel DJ]] | |||
[[Category: Simanshu DK]] | |||
Latest revision as of 12:26, 1 March 2024
Crystal structure of Bacillus subtilis MazF in complex with RNA
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