2nx8: Difference between revisions

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[[Image:2nx8.jpg|left|200px]]<br /><applet load="2nx8" size="350" color="white" frame="true" align="right" spinBox="true"
caption="2nx8, resolution 2.00&Aring;" />
'''The crystal structure of the tRNA-specific adenosine deaminase from Streptococcus pyogenes'''<br />


==About this Structure==
==The crystal structure of the tRNA-specific adenosine deaminase from Streptococcus pyogenes==
2NX8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_pyogenes_mgas8232 Streptococcus pyogenes mgas8232] with <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=PO4:'>PO4</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NX8 OCA].  
<StructureSection load='2nx8' size='340' side='right'caption='[[2nx8]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2nx8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pyogenes_serotype_M6 Streptococcus pyogenes serotype M6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NX8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NX8 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nx8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nx8 OCA], [https://pdbe.org/2nx8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nx8 RCSB], [https://www.ebi.ac.uk/pdbsum/2nx8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nx8 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TADA_STRP6 TADA_STRP6] Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).[HAMAP-Rule:MF_00972]<ref>PMID:17554781</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nx/2nx8_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2nx8 ConSurf].
<div style="clear:both"></div>


==Reference==
==See Also==
Crystal structure of the tRNA-specific adenosine deaminase from Streptococcus pyogenes., Lee WH, Kim YK, Nam KH, Priyadarshi A, Lee EH, Kim EE, Jeon YH, Cheong C, Hwang KY, Proteins. 2007 Sep 1;68(4):1016-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17554781 17554781]
*[[Adenosine deaminase 3D structures|Adenosine deaminase 3D structures]]
[[Category: Single protein]]
== References ==
[[Category: Streptococcus pyogenes mgas8232]]
<references/>
[[Category: Hwang, K Y.]]
__TOC__
[[Category: Kim, Y K.]]
</StructureSection>
[[Category: Lee, W H.]]
[[Category: Large Structures]]
[[Category: PO4]]
[[Category: Streptococcus pyogenes serotype M6]]
[[Category: ZN]]
[[Category: Hwang KY]]
[[Category: adenosine]]
[[Category: Kim YK]]
[[Category: deaminase]]
[[Category: Lee W-H]]
[[Category: hydrolase]]
[[Category: tad]]
[[Category: trna]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:12:01 2008''
Retrieved from "https://proteopedia.org/2nx8"