2nzl: Difference between revisions
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== | ==Crystal structure of human hydroxyacid oxidase 1== | ||
<StructureSection load='2nzl' size='340' side='right'caption='[[2nzl]], [[Resolution|resolution]] 1.35Å' scene=''> | |||
[[ | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2nzl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NZL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NZL FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.35Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GLV:GLYOXYLIC+ACID'>GLV</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nzl OCA], [https://pdbe.org/2nzl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nzl RCSB], [https://www.ebi.ac.uk/pdbsum/2nzl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nzl ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/HAOX1_HUMAN HAOX1_HUMAN] Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate. | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nz/2nzl_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2nzl ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | |||
*[[Glycolate oxidase 3D structures|Glycolate oxidase 3D structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Arrowsmith | [[Category: Arrowsmith CH]] | ||
[[Category: Berridge | [[Category: Berridge G]] | ||
[[Category: Debreczeni | [[Category: Debreczeni JE]] | ||
[[Category: Edwards A]] | |||
[[Category: Edwards | [[Category: Gileadi O]] | ||
[[Category: Gileadi | [[Category: Kavanagh K]] | ||
[[Category: Kavanagh | [[Category: Niesen F]] | ||
[[Category: Niesen | [[Category: Oppermann U]] | ||
[[Category: Oppermann | [[Category: Papagrigoriou E]] | ||
[[Category: Papagrigoriou | [[Category: Pilka E]] | ||
[[Category: Pilka | [[Category: Sundstrom M]] | ||
[[Category: Turnbull A]] | |||
[[Category: Sundstrom | [[Category: Ugochukwu E]] | ||
[[Category: Turnbull | [[Category: Weigelt J]] | ||
[[Category: Ugochukwu | [[Category: Von Delft F]] | ||
[[Category: Weigelt | |||
[[Category: | |||
Latest revision as of 10:27, 30 August 2023
Crystal structure of human hydroxyacid oxidase 1
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