4mk0: Difference between revisions
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New page: '''Unreleased structure''' The entry 4mk0 is ON HOLD Authors: Homan, K.T., Tesmer, J.J.G. Description: Crystal structure of G protein-coupled receptor kinase 2 in complex with a a rati... |
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==Crystal structure of G protein-coupled receptor kinase 2 in complex with a a rationally designed paroxetine derivative== | |||
<StructureSection load='4mk0' size='340' side='right'caption='[[4mk0]], [[Resolution|resolution]] 2.40Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4mk0]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MK0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MK0 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=29X:5-{[(3S,4R)-4-(4-FLUOROPHENYL)PIPERIDIN-3-YL]METHOXY}-1H-ISOINDOL-1-ONE'>29X</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mk0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mk0 OCA], [https://pdbe.org/4mk0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mk0 RCSB], [https://www.ebi.ac.uk/pdbsum/4mk0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mk0 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/ARBK1_HUMAN ARBK1_HUMAN] Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.<ref>PMID:19306925</ref> | |||
==See Also== | |||
*[[Beta adrenergic receptor kinase 3D structures|Beta adrenergic receptor kinase 3D structures]] | |||
*[[Transducin 3D structures|Transducin 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Bos taurus]] | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Homan KT]] | |||
[[Category: Tesmer JJG]] | |||
Latest revision as of 12:27, 1 March 2024
Crystal structure of G protein-coupled receptor kinase 2 in complex with a a rationally designed paroxetine derivative
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