2o2i: Difference between revisions

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[[Image:2o2i.jpg|left|200px]]<br /><applet load="2o2i" size="350" color="white" frame="true" align="right" spinBox="true"
caption="2o2i, resolution 1.500&Aring;" />
'''Crystal structure of haloalkane dehalogenase Rv2579 from Mycobacterium tuberculosis complexed with 1,3-propandiol'''<br />


==About this Structure==
==Crystal structure of haloalkane dehalogenase Rv2579 from Mycobacterium tuberculosis complexed with 1,3-propandiol==
2O2I is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis] with <scene name='pdbligand=BR:'>BR</scene> and <scene name='pdbligand=PDO:'>PDO</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Haloalkane_dehalogenase Haloalkane dehalogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.8.1.5 3.8.1.5] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O2I OCA].
<StructureSection load='2o2i' size='340' side='right'caption='[[2o2i]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
[[Category: Haloalkane dehalogenase]]
== Structural highlights ==
[[Category: Mycobacterium tuberculosis]]
<table><tr><td colspan='2'>[[2o2i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O2I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O2I FirstGlance]. <br>
[[Category: Single protein]]
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
[[Category: Cherney, M M.]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=PDO:1,3-PROPANDIOL'>PDO</scene></td></tr>
[[Category: Garen, C R.]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o2i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o2i OCA], [https://pdbe.org/2o2i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o2i RCSB], [https://www.ebi.ac.uk/pdbsum/2o2i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o2i ProSAT]</span></td></tr>
[[Category: Hulecki, J.]]
</table>
[[Category: James, M N.G.]]
== Function ==
[[Category: Mazumdar, P A.]]
[https://www.uniprot.org/uniprot/DHAA_MYCTU DHAA_MYCTU] Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons (By similarity).[HAMAP-Rule:MF_01231]
[[Category: TBSGC, TB Structural Genomics Consortium.]]
== Evolutionary Conservation ==
[[Category: BR]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: PDO]]
Check<jmol>
[[Category: 1]]
  <jmolCheckbox>
[[Category: 3-propandiol]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o2/2o2i_consurf.spt"</scriptWhenChecked>
[[Category: alpha/beta-hydrolase protein]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: haloalkane dehalogenase]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: mycobacterium tuberculosis]]
  </jmolCheckbox>
[[Category: rv2579]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2o2i ConSurf].
[[Category: tb structural genomics consortium]]
<div style="clear:both"></div>
[[Category: tbsgc]]
__TOC__
[[Category: x-ray crystallography]]
</StructureSection>
 
[[Category: Large Structures]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:13:40 2008''
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Cherney MM]]
[[Category: Garen CR]]
[[Category: Hulecki J]]
[[Category: James MNG]]
[[Category: Mazumdar PA]]
Retrieved from "https://proteopedia.org/2o2i"