4hs2: Difference between revisions
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== | ==Crystal Structure of the Human SPOP C-terminal Domain== | ||
[[http://www.uniprot.org/uniprot/SPOP_HUMAN SPOP_HUMAN | <StructureSection load='4hs2' size='340' side='right'caption='[[4hs2]], [[Resolution|resolution]] 1.53Å' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4hs2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HS2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HS2 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.53Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hs2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hs2 OCA], [https://pdbe.org/4hs2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hs2 RCSB], [https://www.ebi.ac.uk/pdbsum/4hs2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hs2 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/SPOP_HUMAN SPOP_HUMAN] Inhibits IPF1/PDX1 transactivation of established target promoters, such as insulin, may be by recruiting a repressor complex (By similarity). In complex with CUL3, involved in ubiquitination of BMI1, H2AFY and DAXX, and probably also in ubiquitination and proteasomal degradation of Gli2 or Gli3.<ref>PMID:14528312</ref> <ref>PMID:15897469</ref> <ref>PMID:16524876</ref> | |||
== | ==See Also== | ||
[[ | *[[Speckle-type POZ protein 3D structures|Speckle-type POZ protein 3D structures]] | ||
== References == | |||
== | <references/> | ||
<references | __TOC__ | ||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Carr SB]] | ||
[[Category: Stead | [[Category: Stead MA]] | ||
[[Category: | [[Category: Van Geersdaele LK]] | ||
[[Category: | [[Category: Wright SC]] | ||
Latest revision as of 11:44, 1 March 2024
Crystal Structure of the Human SPOP C-terminal Domain
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