2o4f: Difference between revisions
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== | ==Structure of a parallel-stranded guanine tetraplex crystallised with monovalent ions== | ||
<StructureSection load='2o4f' size='340' side='right'caption='[[2o4f]], [[Resolution|resolution]] 1.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2o4f]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O4F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O4F FirstGlance]. <br> | |||
[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LI:LITHIUM+ION'>LI</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | |||
[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o4f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o4f OCA], [https://pdbe.org/2o4f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o4f RCSB], [https://www.ebi.ac.uk/pdbsum/2o4f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o4f ProSAT]</span></td></tr> | ||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
A parallel 5'-d(TGGGGT)-3' quadruplex was formed in Na(+) solution and crystallized using lithium sulfate as the main precipitating agent. The X-ray structure was determined to 1.5 A resolution in space group P2(1) by molecular replacement. The asymmetric unit consists of a characteristic motif of two quadruplexes stacked at their 5' ends. All nucleotides are clearly defined in the density and could be positioned. A single bound Li(+) ion is observed at the surface of the column formed by the two joined molecules. Thus, this small alkali metal ion appears to be unsuitable as a replacement for the Na(+) ion in the central channel of G-quartets, unlike K(+) or Tl(+) ions. A well conserved constellation of water molecules is observed in the grooves of the dimeric structure. | |||
Structure of a d(TGGGGT) quadruplex crystallized in the presence of Li+ ions.,Creze C, Rinaldi B, Haser R, Bouvet P, Gouet P Acta Crystallogr D Biol Crystallogr. 2007 Jun;63(Pt 6):682-8. Epub 2007, May 15. PMID:17505106<ref>PMID:17505106</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 2o4f" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Bouvet P]] | |||
[[Category: Creze C]] | |||
[[Category: Gouet P]] | |||
[[Category: Haser R]] | |||
[[Category: Rinaldi B]] | |||
Latest revision as of 10:30, 30 August 2023
Structure of a parallel-stranded guanine tetraplex crystallised with monovalent ions
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