4km0: Difference between revisions

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'''Unreleased structure'''


The entry 4km0 is ON HOLD  until Paper Publication
==Crystal structure of dihydrofolate reductase from Mycobacterium tuberculosis in complex with pyrimethamine==
<StructureSection load='4km0' size='340' side='right'caption='[[4km0]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4km0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KM0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KM0 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATR:2-MONOPHOSPHOADENOSINE-5-DIPHOSPHATE'>ATR</scene>, <scene name='pdbligand=CP6:5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE'>CP6</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4km0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4km0 OCA], [https://pdbe.org/4km0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4km0 RCSB], [https://www.ebi.ac.uk/pdbsum/4km0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4km0 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DYR_MYCTU DYR_MYCTU] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.


Authors: Dias, M.V.B, Tyrakis, P., Blundell, T.L.
==See Also==
 
*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
Description: Crystal structure of dihydrofolate reductase from Mycobacterium tuberculosis in complex with pyrimethamine
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Blundell TL]]
[[Category: Dias MVB]]
[[Category: Tyrakis P]]
Retrieved from "https://proteopedia.org/4km0"