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{{STRUCTURE_3dw8|  PDB=3dw8  |  SCENE=  }}
===Structure of a Protein Phosphatase 2A Holoenzyme with B55 subunit===
{{ABSTRACT_PUBMED_18922469}}


==Function==
==Structure of a Protein Phosphatase 2A Holoenzyme with B55 subunit==
[[http://www.uniprot.org/uniprot/2AAA_HUMAN 2AAA_HUMAN]] The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Required for proper chromosome segregation and for centromeric localization of SGOL1 in mitosis.<ref>PMID:16580887</ref> [[http://www.uniprot.org/uniprot/PP2AA_HUMAN PP2AA_HUMAN]] PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259'.<ref>PMID:9920888</ref> <ref>PMID:10801873</ref> <ref>PMID:22613722</ref> [[http://www.uniprot.org/uniprot/2ABA_HUMAN 2ABA_HUMAN]] The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
<StructureSection load='3dw8' size='340' side='right'caption='[[3dw8]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[3dw8]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Cyanobacteria Cyanobacteria] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DW8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DW8 FirstGlance]. <br>
[[3dw8]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DW8 OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.85&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1ZN:(2S,3S,4E,6E,8S,9S)-3-AMINO-9-METHOXY-2,6,8-TRIMETHYL-10-PHENYLDECA-4,6-DIENOIC+ACID'>1ZN</scene>, <scene name='pdbligand=ACB:3-METHYL-BETA-D-ASPARTIC+ACID'>ACB</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DAM:N-METHYL-ALPHA-BETA-DEHYDROALANINE'>DAM</scene>, <scene name='pdbligand=FGA:GAMMA-D-GLUTAMIC+ACID'>FGA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dw8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dw8 OCA], [https://pdbe.org/3dw8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dw8 RCSB], [https://www.ebi.ac.uk/pdbsum/3dw8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dw8 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/2AAA_HUMAN 2AAA_HUMAN] The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Required for proper chromosome segregation and for centromeric localization of SGOL1 in mitosis.<ref>PMID:16580887</ref>  
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dw/3dw8_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dw8 ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Protein phosphatase|Protein phosphatase]]
*[[Protein phosphatase 3D structures|Protein phosphatase 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:018922469</ref><references group="xtra"/><references/>
__TOC__
</StructureSection>
[[Category: Cyanobacteria]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Phosphoprotein phosphatase]]
[[Category: Large Structures]]
[[Category: Chen, Y.]]
[[Category: Chen Y]]
[[Category: Jeffrey, P D.]]
[[Category: Jeffrey PD]]
[[Category: Shi, Y.]]
[[Category: Shi Y]]
[[Category: Xu, Y.]]
[[Category: Xu Y]]
[[Category: Zhang, P.]]
[[Category: Zhang P]]
[[Category: B55]]
[[Category: Holoenzyme]]
[[Category: Hydrolase]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Iron]]
[[Category: Manganese]]
[[Category: Metal-binding]]
[[Category: Methylation]]
[[Category: Phosphoprotein]]
[[Category: Pr55]]
[[Category: Protein phosphatase]]
[[Category: Wd repeat]]

Latest revision as of 06:36, 3 April 2024

Structure of a Protein Phosphatase 2A Holoenzyme with B55 subunit

3dw8, resolution 2.85Å

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