1w4s: Difference between revisions

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[[Image:1w4s.gif|left|200px]]<br />
<applet load="1w4s" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1w4s, resolution 1.55&Aring;" />
'''CRYSTAL STRUCTURE OF THE PROXIMAL BAH DOMAIN OF POLYBROMO'''<br />


==Overview==
==Crystal structure of the proximal BAH domain of polybromo==
The BAH domain (bromo-associated homology domain) was first identified, from a repeated motif found in the nuclear protein polybromo--a large (187, kDa) modular protein comprising six bromodomains, two BAH domains and an, HMG box. To date, the BAH domain has no ascribed function, although it is, found in a wide range of proteins that contain additional domains involved, in either transcriptional regulation (e.g. SET, PHD and bromodomain), and/or DNA binding (HMG box and AT hook). The molecular function of, polybromo itself also remains unclear, but it has been identified as a key, component of an SWI/SNF (switching/sucrose non-fermenting)-related, ATP-dependent chromatin-remodelling complex PBAF (polybromo, BRG1-associated factors; also known as SWI/SNF-B or SWI/SNFbeta). We, present in ... [[http://ispc.weizmann.ac.il/pmbin/getpm?15839835 (full description)]]
<StructureSection load='1w4s' size='340' side='right'caption='[[1w4s]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1w4s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W4S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W4S FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w4s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w4s OCA], [https://pdbe.org/1w4s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w4s RCSB], [https://www.ebi.ac.uk/pdbsum/1w4s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w4s ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PB1_CHICK PB1_CHICK] Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w4/1w4s_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1w4s ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The BAH domain (bromo-associated homology domain) was first identified from a repeated motif found in the nuclear protein polybromo--a large (187 kDa) modular protein comprising six bromodomains, two BAH domains and an HMG box. To date, the BAH domain has no ascribed function, although it is found in a wide range of proteins that contain additional domains involved in either transcriptional regulation (e.g. SET, PHD and bromodomain) and/or DNA binding (HMG box and AT hook). The molecular function of polybromo itself also remains unclear, but it has been identified as a key component of an SWI/SNF (switching/sucrose non-fermenting)-related, ATP-dependent chromatin-remodelling complex PBAF (polybromo, BRG1-associated factors; also known as SWI/SNF-B or SWI/SNFbeta). We present in this paper the crystal structure of the proximal BAH domain from chicken polybromo (BAH1), at a resolution of 1.6 A (1 A=0.1 nm). Structure-based sequence analysis reveals several features that may be involved in mediating protein-protein interactions.


==About this Structure==
Crystal structure of the proximal BAH domain of the polybromo protein.,Oliver AW, Jones SA, Roe SM, Matthews S, Goodwin GH, Pearl LH Biochem J. 2005 Aug 1;389(Pt 3):657-64. PMID:15839835<ref>PMID:15839835</ref>
1W4S is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]] with CL as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W4S OCA]].


==Reference==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
Crystal structure of the proximal BAH domain of the polybromo protein., Oliver AW, Jones SA, Roe SM, Matthews S, Goodwin GH, Pearl LH, Biochem J. 2005 Aug 1;389(Pt 3):657-64. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15839835 15839835]
</div>
<div class="pdbe-citations 1w4s" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Oliver, A.W.]]
[[Category: Oliver AW]]
[[Category: Pearl, L.H.]]
[[Category: Pearl LH]]
[[Category: Roe, S.M.]]
[[Category: Roe SM]]
[[Category: CL]]
[[Category: bah]]
[[Category: bromo-associated homology domain]]
[[Category: chromatin remodelling]]
[[Category: nuclear protein]]
[[Category: pbaf]]
[[Category: polybromo]]
[[Category: rsc]]
[[Category: swi/snf-b]]
 
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Retrieved from "https://proteopedia.org/1w4s"