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{{STRUCTURE_4lvb|  PDB=4lvb  |  SCENE=  }}
===Fragment-based Identification of Amides Derived From trans-2-(Pyridin-3-yl)cyclopropanecarboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)===
{{ABSTRACT_PUBMED_24021463}}


==Function==
==Fragment-based Identification of Amides Derived From trans-2-(Pyridin-3-yl)cyclopropanecarboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)==
[[http://www.uniprot.org/uniprot/NAMPT_HUMAN NAMPT_HUMAN]] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).  
<StructureSection load='4lvb' size='340' side='right'caption='[[4lvb]], [[Resolution|resolution]] 1.84&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4lvb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LVB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LVB FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.836&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=20N:N-[4-(ACETYLAMINO)PHENYL]CYCLOPROPANECARBOXAMIDE'>20N</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lvb OCA], [https://pdbe.org/4lvb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lvb RCSB], [https://www.ebi.ac.uk/pdbsum/4lvb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lvb ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NAMPT_HUMAN NAMPT_HUMAN] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).


==About this Structure==
==See Also==
[[4lvb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LVB OCA].
*[[Phosphoribosyltransferase 3D structures|Phosphoribosyltransferase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:024021463</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Nicotinamide phosphoribosyltransferase]]
[[Category: Large Structures]]
[[Category: Bravo, B.]]
[[Category: Bravo B]]
[[Category: Brien, T O.]]
[[Category: Dragovich PS]]
[[Category: Dragovich, P S.]]
[[Category: Feng Y]]
[[Category: Feng, Y.]]
[[Category: Giannetti AM]]
[[Category: Giannetti, A M.]]
[[Category: Gunzner-Toste J]]
[[Category: Gunzner-Toste, J.]]
[[Category: Ho Y]]
[[Category: Ho, Y.]]
[[Category: Hua R]]
[[Category: Hua, R.]]
[[Category: Liederer BM]]
[[Category: Liederer, B M.]]
[[Category: Liu Y]]
[[Category: Liu, Y.]]
[[Category: O'Brien T]]
[[Category: Oeh, J.]]
[[Category: Oeh J]]
[[Category: Sampath, D.]]
[[Category: Sampath D]]
[[Category: Shen, Y.]]
[[Category: Shen Y]]
[[Category: Skelton, N.]]
[[Category: Skelton N]]
[[Category: Wang, C.]]
[[Category: Wang C]]
[[Category: Wang, L.]]
[[Category: Wang L]]
[[Category: Wang, W.]]
[[Category: Wang W]]
[[Category: Wu, H.]]
[[Category: Wu H]]
[[Category: Xiao, Y.]]
[[Category: Xiao Y]]
[[Category: Yuen, P.]]
[[Category: Yuen P]]
[[Category: Zak, M.]]
[[Category: Zak M]]
[[Category: Zhao, G.]]
[[Category: Zhao G]]
[[Category: Zhao, Q.]]
[[Category: Zhao Q]]
[[Category: Zheng, X.]]
[[Category: Zheng X]]
[[Category: Transferase]]
[[Category: Transferase-transferase inhibitor complex]]
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