4jby: Difference between revisions
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== | ==Crystal structure of thymidine kinase from Herpes simplex virus type 1 in complex with F-SK78== | ||
[[ | <StructureSection load='4jby' size='340' side='right'caption='[[4jby]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | |||
== | <table><tr><td colspan='2'>[[4jby]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_alphaherpesvirus_1_strain_17 Human alphaherpesvirus 1 strain 17]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JBY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JBY FirstGlance]. <br> | ||
[[4jby]] is a 2 chain structure with sequence from [ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FSK:6-[(1Z)-3-FLUORO-2-(HYDROXYMETHYL)PROP-1-EN-1-YL]-1,5-DIMETHYLPYRIMIDINE-2,4(1H,3H)-DIONE'>FSK</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jby OCA], [https://pdbe.org/4jby PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jby RCSB], [https://www.ebi.ac.uk/pdbsum/4jby PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jby ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/KITH_HHV11 KITH_HHV11] In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome (By similarity). | |||
==See Also== | ==See Also== | ||
*[[Thymidine kinase|Thymidine kinase]] | *[[Thymidine kinase 3D structures|Thymidine kinase 3D structures]] | ||
__TOC__ | |||
</StructureSection> | |||
< | [[Category: Human alphaherpesvirus 1 strain 17]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Novakovic | [[Category: Novakovic I]] | ||
[[Category: Pernot | [[Category: Pernot L]] | ||
[[Category: Perozzo | [[Category: Perozzo R]] | ||
[[Category: Raic-Malic | [[Category: Raic-Malic S]] | ||
[[Category: Scapozza | [[Category: Scapozza L]] | ||
[[Category: Westermaier | [[Category: Westermaier Y]] | ||
Latest revision as of 15:39, 20 September 2023
Crystal structure of thymidine kinase from Herpes simplex virus type 1 in complex with F-SK78
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