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[[Image:2omj.jpg|left|200px]]<br /><applet load="2omj" size="350" color="white" frame="true" align="right" spinBox="true"
caption="2omj" />
'''solution structure of LARG PDZ domain'''<br />


==About this Structure==
==solution structure of LARG PDZ domain==
2OMJ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OMJ OCA].  
<StructureSection load='2omj' size='340' side='right'caption='[[2omj]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2omj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OMJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OMJ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2omj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2omj OCA], [https://pdbe.org/2omj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2omj RCSB], [https://www.ebi.ac.uk/pdbsum/2omj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2omj ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/ARHGC_HUMAN ARHGC_HUMAN] Note=A chromosomal aberration involving ARHGEF12 may be a cause of acute leukemia. Translocation t(11;11)(q23;23) with MLL.
== Function ==
[https://www.uniprot.org/uniprot/ARHGC_HUMAN ARHGC_HUMAN] May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13.<ref>PMID:11094164</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/om/2omj_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2omj ConSurf].
<div style="clear:both"></div>
 
==See Also==
*[[Rho guanine nucleotide exchange factor 3D structures|Rho guanine nucleotide exchange factor 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Hu, Q.]]
[[Category: Hu Q]]
[[Category: Huang, H.]]
[[Category: Huang H]]
[[Category: Liu, J.]]
[[Category: Liu J]]
[[Category: actin reorganization]]
[[Category: cell adhesion]]
[[Category: nerve system development]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:20:06 2008''
Retrieved from "https://proteopedia.org/2omj"