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| [[Image:2onw.gif|left|200px]]<br /><applet load="2onw" size="350" color="white" frame="true" align="right" spinBox="true"
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| caption="2onw, resolution 1.510Å" />
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| '''Structure of SSTSSA, a fibril forming peptide from Bovine Pancreatic Ribonuclease (RNase A, residues 15-20)'''<br />
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| ==Overview== | | ==Structure of SSTSSA, a fibril forming peptide from Bovine Pancreatic Ribonuclease (RNase A, residues 15-20)== |
| Amyloid fibrils formed from different proteins, each associated with a particular disease, contain a common cross-beta spine. The atomic architecture of a spine, from the fibril-forming segment GNNQQNY of the yeast prion protein Sup35, was recently revealed by X-ray microcrystallography. It is a pair of beta-sheets, with the facing side chains of the two sheets interdigitated in a dry 'steric zipper'. Here we report some 30 other segments from fibril-forming proteins that form amyloid-like fibrils, microcrystals, or usually both. These include segments from the Alzheimer's amyloid-beta and tau proteins, the PrP prion protein, insulin, islet amyloid polypeptide (IAPP), lysozyme, myoglobin, alpha-synuclein and beta(2)-microglobulin, suggesting that common structural features are shared by amyloid diseases at the molecular level. Structures of 13 of these microcrystals all reveal steric zippers, but with variations that expand the range of atomic architectures for amyloid-like fibrils and offer an atomic-level hypothesis for the basis of prion strains.
| | <StructureSection load='2onw' size='340' side='right'caption='[[2onw]], [[Resolution|resolution]] 1.51Å' scene=''> |
| | | == Structural highlights == |
| ==About this Structure== | | <table><tr><td colspan='2'>[[2onw]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ONW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ONW FirstGlance]. <br> |
| 2ONW is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ONW OCA].
| | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.51Å</td></tr> |
| | | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2onw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2onw OCA], [https://pdbe.org/2onw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2onw RCSB], [https://www.ebi.ac.uk/pdbsum/2onw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2onw ProSAT]</span></td></tr> |
| ==Reference== | | </table> |
| Atomic structures of amyloid cross-beta spines reveal varied steric zippers., Sawaya MR, Sambashivan S, Nelson R, Ivanova MI, Sievers SA, Apostol MI, Thompson MJ, Balbirnie M, Wiltzius JJ, McFarlane HT, Madsen AO, Riekel C, Eisenberg D, Nature. 2007 May 24;447(7143):453-7. Epub 2007 Apr 29. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17468747 17468747]
| | __TOC__ |
| [[Category: Protein complex]] | | </StructureSection> |
| [[Category: Eisenberg, D.]]
| | [[Category: Large Structures]] |
| [[Category: Sambashivan, S.]] | | [[Category: Eisenberg D]] |
| [[Category: Sawaya, M R.]] | | [[Category: Sambashivan S]] |
| [[Category: parallel face-to-face-up/up beta sheets]] | | [[Category: Sawaya MR]] |
| [[Category: steric zipper]] | |
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| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:20:32 2008''
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