2m8a: Difference between revisions

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'''Unreleased structure'''


The entry 2m8a is ON HOLD  until Paper Publication
==2'F-ANA/2'F-RNA alternated sequences==
<StructureSection load='2m8a' size='340' side='right'caption='[[2m8a]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2m8a]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M8A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M8A FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AF2:2-DEOXY-2-FLUOROADENOSINE+5-(DIHYDROGEN+PHOSPHATE)'>AF2</scene>, <scene name='pdbligand=CFL:4-AMINO-1-(2-DEOXY-2-FLUORO-5-O-PHOSPHONO-BETA-D-ARABINOFURANOSYL)PYRIMIDIN-2(1H)-ONE'>CFL</scene>, <scene name='pdbligand=CFZ:2-DEOXY-2-FLUOROCYTIDINE+5-(DIHYDROGEN+PHOSPHATE)'>CFZ</scene>, <scene name='pdbligand=GF2:2-DEOXY-2-FLUOROGUANOSINE+5-(DIHYDROGEN+PHOSPHATE)'>GF2</scene>, <scene name='pdbligand=TAF:2-DEOXY-2-FLUORO-ARABINO-FURANOSYL+THYMINE-5-PHOSPHATE'>TAF</scene>, <scene name='pdbligand=UFT:2-DEOXY-2-FLUOROURIDINE+5-(DIHYDROGEN+PHOSPHATE)'>UFT</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m8a OCA], [https://pdbe.org/2m8a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m8a RCSB], [https://www.ebi.ac.uk/pdbsum/2m8a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m8a ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Polarizing CHO hydrogen bonds: The structure of oligonucleotides containing alternating and contiguous tracts of 2'F-RNA and 2'F-ANA nucleotides reveals that nonconventional FCHO hydrogen bonds have a strong stabilizing effect on 2'-fluorinated duplexes.


Authors: Martin-Pintado, N., Deleavey, G., Portella, G., Campos, R., Orozco, M., Damha, M., Gonzalez, C.
Backbone FCHO Hydrogen Bonds in 2'F-Substituted Nucleic Acids.,Martin-Pintado N, Deleavey GF, Portella G, Campos-Olivas R, Orozco M, Damha MJ, Gonzalez C Angew Chem Int Ed Engl. 2013 Sep 23. doi: 10.1002/anie.201305710. PMID:24115468<ref>PMID:24115468</ref>


Description: 2'F-ANA/2'F-RNA alternated sequences
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2m8a" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Campos R]]
[[Category: Damha M]]
[[Category: Deleavey G]]
[[Category: Gonzalez C]]
[[Category: Martin-Pintado N]]
[[Category: Orozco M]]
[[Category: Portella G]]
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