2osz: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
 
(14 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:2osz.gif|left|200px]]<br /><applet load="2osz" size="350" color="white" frame="true" align="right" spinBox="true"
caption="2osz, resolution 2.85&Aring;" />
'''Structure of Nup58/45 suggests flexible nuclear pore diameter by intermolecular sliding'''<br />


==Overview==
==Structure of Nup58/45 suggests flexible nuclear pore diameter by intermolecular sliding==
The nucleoporins Nup58 and Nup45 are part of the central transport channel of the nuclear pore complex, which is thought to have a flexible diameter. In the crystal structure of an alpha-helical region of mammalian Nup58/45, we identified distinct tetramers, each consisting of two antiparallel hairpin dimers. The intradimeric interface is hydrophobic, whereas dimer-dimer association occurs through large hydrophilic residues. These residues are laterally displaced in various tetramer conformations, which suggests an intermolecular sliding by 11 angstroms. We propose that circumferential sliding plays a role in adjusting the diameter of the central transport channel.
<StructureSection load='2osz' size='340' side='right'caption='[[2osz]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2osz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OSZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OSZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.85&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2osz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2osz OCA], [https://pdbe.org/2osz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2osz RCSB], [https://www.ebi.ac.uk/pdbsum/2osz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2osz ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NUP58_RAT NUP58_RAT] Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane.<ref>PMID:8707840</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/os/2osz_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2osz ConSurf].
<div style="clear:both"></div>


==About this Structure==
==See Also==
2OSZ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OSZ OCA].
*[[Nucleoporin 3D structures|Nucleoporin 3D structures]]
 
== References ==
==Reference==
<references/>
Structure of Nup58/45 suggests flexible nuclear pore diameter by intermolecular sliding., Melcak I, Hoelz A, Blobel G, Science. 2007 Mar 23;315(5819):1729-32. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17379812 17379812]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Single protein]]
[[Category: Blobel G]]
[[Category: Blobel, G.]]
[[Category: Hoelz A]]
[[Category: Hoelz, A.]]
[[Category: Melcak I]]
[[Category: Melcak, I.]]
[[Category: npc]]
[[Category: nucleoporin]]
[[Category: structure]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:22:13 2008''
Retrieved from "https://proteopedia.org/2osz"