4n5b: Difference between revisions
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New page: '''Unreleased structure''' The entry 4n5b is ON HOLD Authors: Bruhn-Johannsen, J.F., Barnett, K., Bibby, J., Thomas, J., Keegan, R., Rigden, D., Bornholdt, Z.A., Saphire, E.O. Descript... |
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The | ==Crystal structure of the Nipah virus phosphoprotein tetramerization domain== | ||
<StructureSection load='4n5b' size='340' side='right'caption='[[4n5b]], [[Resolution|resolution]] 2.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4n5b]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Nipah_henipavirus Nipah henipavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N5B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N5B FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n5b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n5b OCA], [https://pdbe.org/4n5b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n5b RCSB], [https://www.ebi.ac.uk/pdbsum/4n5b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n5b ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/D2DEB8_NIPAV D2DEB8_NIPAV] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The Nipah virus phosphoprotein, P, is multimeric and tethers the viral polymerase to the nucleocapsid. We present the crystal structure of the multimerization domain of Nipah P: a long, parallel, tetrameric, coiled coil with a small, alpha-helical cap structure. Across the paramyxoviruses, these domains share little sequence identity; yet retain similar length and structural organization, suggesting a common requirement for scaffolding or spatial organization of the functions of P in the virus life cycle. | |||
Crystal structure of the Nipah virus phosphoprotein tetramerization domain.,Bruhn-Johannsen JF, Barnett K, Bibby J, Thomas J, Keegan R, Rigden D, Bornholdt ZA, Saphire EO J Virol. 2013 Oct 23. PMID:24155387<ref>PMID:24155387</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 4n5b" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Nipah henipavirus]] | |||
[[Category: Barnett K]] | |||
[[Category: Bibby J]] | |||
[[Category: Bornholdt ZA]] | |||
[[Category: Bruhn JF]] | |||
[[Category: Keegan R]] | |||
[[Category: Rigden D]] | |||
[[Category: Saphire EO]] | |||
[[Category: Thomas J]] | |||
