4n5d: Difference between revisions
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New page: '''Unreleased structure''' The entry 4n5d is ON HOLD until Paper Publication Authors: Murray, J.M., Steffek, M. Description: Tailoring Small Molecules for an Allosteric Site on Procasp... |
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==Tailoring Small Molecules for an Allosteric Site on Procaspase-6: Cpd1== | |||
<StructureSection load='4n5d' size='340' side='right'caption='[[4n5d]], [[Resolution|resolution]] 2.06Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4n5d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N5D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N5D FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.06Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2FQ:6-AMINO-2,8-DIMETHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE'>2FQ</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n5d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n5d OCA], [https://pdbe.org/4n5d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n5d RCSB], [https://www.ebi.ac.uk/pdbsum/4n5d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n5d ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/CASP6_HUMAN CASP6_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death. | |||
==See Also== | |||
*[[Caspase 3D structures|Caspase 3D structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Murray JM]] | |||
[[Category: Steffek M]] | |||
Latest revision as of 12:31, 1 March 2024
Tailoring Small Molecules for an Allosteric Site on Procaspase-6: Cpd1
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