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{{STRUCTURE_4jir|  PDB=4jir  |  SCENE=  }}
===Crystal Structure Of Aldose Reductase (AKR1B1) Complexed With NADP+ And Epalrestat===
{{ABSTRACT_PUBMED_24100137}}


==Function==
==Crystal Structure Of Aldose Reductase (AKR1B1) Complexed With NADP+ And Epalrestat==
[[http://www.uniprot.org/uniprot/ALDR_HUMAN ALDR_HUMAN]] Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.  
<StructureSection load='4jir' size='340' side='right'caption='[[4jir]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4jir]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JIR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JIR FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPR:{5-[(2E)-2-METHYL-3-PHENYLPROP-2-EN-1-YLIDENE]-4-OXO-2-THIOXO-1,3-THIAZOLIDIN-3-YL}ACETIC+ACID'>EPR</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jir FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jir OCA], [https://pdbe.org/4jir PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jir RCSB], [https://www.ebi.ac.uk/pdbsum/4jir PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jir ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ALDR_HUMAN ALDR_HUMAN] Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.


==About this Structure==
==See Also==
[[4jir]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JIR OCA].
*[[Aldose reductase 3D structures|Aldose reductase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:024100137</ref><references group="xtra"/><references/>
[[Category: Aldehyde reductase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Chen, K.]]
[[Category: Large Structures]]
[[Category: Hu, X.]]
[[Category: Chen K]]
[[Category: Zhai, J.]]
[[Category: Hu X]]
[[Category: Zhang, H..]]
[[Category: Zhai J]]
[[Category: Zhang, L.]]
[[Category: Zhang H]]
[[Category: Zhao, Y.]]
[[Category: Zhang L]]
[[Category: Zheng, X.]]
[[Category: Zhao Y]]
[[Category: Oxidoreductase]]
[[Category: Zheng X]]
[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
[[Category: Tim barrel]]
Retrieved from "https://proteopedia.org/4jir"