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{{STRUCTURE_1wnb|  PDB=1wnb  |  SCENE=  }}
===Escherichia coli YdcW gene product is a medium-chain aldehyde dehydrogenase (complexed with nadh and betaine aldehyde)===
{{ABSTRACT_PUBMED_15381418}}


==Function==
==Escherichia coli YdcW gene product is a medium-chain aldehyde dehydrogenase (complexed with nadh and betaine aldehyde)==
[[http://www.uniprot.org/uniprot/ABDH_ECOLI ABDH_ECOLI]] Catalyzes the oxidation of 1-pyrroline, which is spontaneously formed from 4-aminobutanal, leading to 4-aminobutanoate (GABA). Can also oxidize n-alkyl medium-chain aldehydes, but with a lower catalytic efficiency.<ref>PMID:16023116</ref> <ref>PMID:15381418</ref>
<StructureSection load='1wnb' size='340' side='right'caption='[[1wnb]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[1wnb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WNB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WNB FirstGlance]. <br>
[[1wnb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WNB OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTL:BETAINE+ALDEHYDE'>BTL</scene>, <scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene></td></tr>
==Reference==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wnb OCA], [https://pdbe.org/1wnb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wnb RCSB], [https://www.ebi.ac.uk/pdbsum/1wnb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wnb ProSAT]</span></td></tr>
<ref group="xtra">PMID:015381418</ref><references group="xtra"/><references/>
</table>
[[Category: Betaine-aldehyde dehydrogenase]]
== Function ==
[[Category: Escherichia coli k-12]]
[https://www.uniprot.org/uniprot/ABDH_ECOLI ABDH_ECOLI] Catalyzes the oxidation of 1-pyrroline, which is spontaneously formed from 4-aminobutanal, leading to 4-aminobutanoate (GABA). Can also oxidize n-alkyl medium-chain aldehydes, but with a lower catalytic efficiency.<ref>PMID:16023116</ref> <ref>PMID:15381418</ref>  
[[Category: Cambillau, C.]]
== Evolutionary Conservation ==
[[Category: Gruez, A.]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: Roig-Zamboni, V.]]
Check<jmol>
[[Category: Tegoni, M.]]
  <jmolCheckbox>
[[Category: Aldehyde dehydrogenase]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wn/1wnb_consurf.spt"</scriptWhenChecked>
[[Category: Flurorescence]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: Kinetic]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: Nadh]]
  </jmolCheckbox>
[[Category: Oxidoreductase]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wnb ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Escherichia coli K-12]]
[[Category: Large Structures]]
[[Category: Cambillau C]]
[[Category: Gruez A]]
[[Category: Roig-Zamboni V]]
[[Category: Tegoni M]]
Retrieved from "https://proteopedia.org/1wnb"