4m7l: Difference between revisions

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'''Unreleased structure'''


The entry 4m7l is ON HOLD  until Paper Publication
==Crystal structure of the complex between human tissue factor extracellular domain and antibody 10H10 FAB fragment==
<StructureSection load='4m7l' size='340' side='right'caption='[[4m7l]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4m7l]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M7L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M7L FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m7l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m7l OCA], [https://pdbe.org/4m7l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m7l RCSB], [https://www.ebi.ac.uk/pdbsum/4m7l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m7l ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TF_HUMAN TF_HUMAN] Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.<ref>PMID:12652293</ref>


Authors: Teplyakov, A., Obmolova, G., Malia, T., Gilliland, G.L.
==See Also==
 
*[[Tissue factor|Tissue factor]]
Description: Crystal structure of the complex between human tissue factor extracellular domain and antibody 10H10 FAB fragment
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Gilliland GL]]
[[Category: Malia T]]
[[Category: Obmolova G]]
[[Category: Teplyakov A]]
Retrieved from "https://proteopedia.org/4m7l"